Skip to content

Study · Animal study (in vivo) · mouse · 2018

4 results

Effects of Chronic NAD Supplementation on Energy Metabolism and Diurnal Rhythm in Obese Mice.

Roh E, Myoung Kang G, Young Gil S, Hee Lee C, Kim S, Hong D, Hoon Son G, Kim MS

Obesity (Silver Spring, Md.)1 Sept 2018Cited by 23 (Europe PMC)

PMID30230244 (opens in a new tab)DOI10.1002/oby.22263 (opens in a new tab)PepBankPUB-30230244
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In HFD-fed obese mice, chronic NAD supplementation reduced weight gain versus saline.

    In plain wordsIn obese mice fed a high-fat diet, NAD reduced weight gain compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseWeight gain
    Study

    mousen: not reported in source

    HFD-fed C57BL/6 obese mice
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1 mg/kg/day · intraperitoneal · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Chronic NAD supplementation significantly attenuated weight gain in HFD-fed obese mice.
    1 context sentence
    Summary · context
    C57BL/6 mice were fed a high-fat diet (HFD) for 12 weeks and received an intraperitoneal injection of either saline or NAD (1 mg/kg/day) for the last 4 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NAD restored suppressed diurnal locomotor activity rhythms versus saline.

    In plain wordsIn obese mice, NAD restored suppressed daily activity rhythms compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseDiurnal locomotor activity rhythms
    Study

    mousen: not reported in source

    HFD-fed C57BL/6 obese mice
    Comparator
    Saline
    Outcome group
    Exercise and physical function · Metabolic and weight
    Studied dose
    1 mg/kg/day · intraperitoneal · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, NAD treatment recovered the suppressed rhythms in the diurnal locomotor activity patterns in obese mice.
    1 context sentence
    Summary · context
    C57BL/6 mice were fed a high-fat diet (HFD) for 12 weeks and received an intraperitoneal injection of either saline or NAD (1 mg/kg/day) for the last 4 weeks.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In obese mice, NAD rescued blunted daily fluctuations of hypothalamic arcuate nucleus PER1 expression versus saline.

    In plain wordsIn obese mice, NAD restored reduced daily fluctuations of hypothalamic PER1 expression compared with saline.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseArcuate nucleus PER1 fluctuations
    Study

    mousen: not reported in source

    HFD-fed C57BL/6 obese mice
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    1 mg/kg/day · intraperitoneal · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    In addition, exogenous NAD supply rescued cellular NAD depletion-induced suppression of PER1 transcriptional activity in hypothalamic neuron cells as well as blunted daily fluctuations of hypothalamic arcuate nucleus PER1 expression in obese mice.
    1 context sentence
    Summary · context
    C57BL/6 mice were fed a high-fat diet (HFD) for 12 weeks and received an intraperitoneal injection of either saline or NAD (1 mg/kg/day) for the last 4 weeks.
  4. 04LabIn vitro (cells)Mechanism

    In hypothalamic neuron cells, NAD rescued suppression of PER1 transcriptional activity induced by cellular NAD depletion.

    In plain wordsIn cells, NAD restored PER1 transcriptional activity suppressed by NAD depletion.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreasePER1 transcriptional activity
    Study

    n: not reported in source

    Hypothalamic neuron cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, exogenous NAD supply rescued cellular NAD depletion-induced suppression of PER1 transcriptional activity in hypothalamic neuron cells as well as blunted daily fluctuations of hypothalamic arcuate nucleus PER1 expression in obese mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.