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Study · Animal study (in vivo) · 2018

3 results

Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration.

Song Y, Li S, Geng W, Luo R, Liu W, Tu J, Wang K, Kang L, Yin H, Wu X, Gao Y, Zhang Y, Yang C

Redox biology6 Sept 2018Cited by 173 (Europe PMC)

PMID30216853 (opens in a new tab)PMCIDPMC6139007 (opens in a new tab)DOI10.1016/j.redox.2018.09.006 (opens in a new tab)PepBankPUB-30216853
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In an in vivo model, NMN protected against AGEs-induced intervertebral disc degeneration.

    In plain wordsIn an animal model, NMN protected against disc degeneration induced by advanced glycation end products.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseIntervertebral disc degeneration
    Study

    n: not reported in source

    AGEs-induced intervertebral disc degeneration
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, based on findings that nicotinamide mononucleotide (NMN) could restore SIRT3 function and rescue human NP cell apoptosis through adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor-γ coactivator 1α (AMPK-PGC-1α) pathway in vitro, we confirmed its…
  2. 02LabIn vitro (cells)Mechanism

    In AGEs-treated human nucleus pulposus cells, NMN restored SIRT3 function through the AMPK-PGC-1α pathway.

    In plain wordsIn cells, NMN restored SIRT3 function through the AMPK-PGC-1α pathway.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSIRT3 function
    Study

    humann: not reported in source

    AGEs-treated human nucleus pulposus cells
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, based on findings that nicotinamide mononucleotide (NMN) could restore SIRT3 function and rescue human NP cell apoptosis through adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor-γ coactivator 1α (AMPK-PGC-1α) pathway in vitro, we confirmed its…
  3. 03LabIn vitro (cells)Efficacy outcome

    In AGEs-treated human nucleus pulposus cells, NMN reduced apoptosis through the AMPK-PGC-1α pathway.

    In plain wordsIn cells, NMN reduced nucleus pulposus cell death through the AMPK-PGC-1α pathway.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseNucleus pulposus cell apoptosis
    Study

    humann: not reported in source

    AGEs-treated human nucleus pulposus cells
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, based on findings that nicotinamide mononucleotide (NMN) could restore SIRT3 function and rescue human NP cell apoptosis through adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor-γ coactivator 1α (AMPK-PGC-1α) pathway in vitro, we confirmed its…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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