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Study · In vitro (cells) · 2018

4 results

Engineering recombinant Lactococcus lactis as a delivery vehicle for BPC-157 peptide with antioxidant activities.

Škrlec K, Ručman R, Jarc E, Sikirić P, Švajger U, Petan T, Perišić Nanut M, Štrukelj B, Berlec A

Applied microbiology and biotechnology6 Sept 2018Cited by 16 (Europe PMC)

PMID30191288 (opens in a new tab)DOI10.1007/s00253-018-9333-6 (opens in a new tab)PepBankPUB-30191288
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In 149BR fibroblasts, secreted BPC‑157 significantly decreased reactive oxygen species production.

    In plain wordsIn lab-grown fibroblast cells, BPC‑157 released by engineered bacteria significantly lowered reactive oxygen species.

    Peptide
    BPC-157
    Outcome
    DecreaseROS production
    Study

    n: not reported in source

    149BR fibroblast cell model
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Secreted BPC-157 significantly decreased ROS production in 149BR fibroblast cell model, suggesting its potential benefit in the treatment of intestinal inflammations.

Studies that did not test the peptide alone3

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 02LabNot a test of BPC-157 aloneIn vitro (cells)Other

    In recombinant L. lactis, surface display of BPC‑157 was approximately 14-fold higher with the AcmA/Usp45 fusion protein than with the BmpA fusion, although BmpA fusion expression was higher.

    In plain wordsIn bacteria engineered to carry BPC‑157, the AcmA/Usp45 fusion displayed about 14 times more peptide on the surface than the BmpA fusion.

    Peptide
    BPC-157
    Outcome
    IncreaseSurface display of BPC-157 by AcmA/Usp45 versus BmpA fusion
    Study

    Lactococcus lactisn: not reported in source

    Recombinant Lactococcus lactis
    Comparator
    BmpA-fusion protein
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Surface display fold difference
    ≈ 14 fold
    AcmA/Usp45 vs BmpA fusion

    Source sentences

    Summary
    While the expression of BmpA-fusion proteins was higher than that of AcmA/Usp45-fusion protein, the surface display ability of BPC-157 was approximately 14-fold higher with AcmA/Usp45-fusion protein.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  2. 03LabNot a test of BPC-157 aloneIn vitro (cells)Other

    In recombinant L. lactis, surface display via AcmA/Usp45 fusion delivered BPC‑157 at 30 ng/ml.

    In plain wordsIn engineered bacteria, surface display released BPC‑157 at 30 ng/ml.

    Peptide
    BPC-157
    Outcome
    Not applicableBPC-157 concentration by surface display
    Study

    Lactococcus lactisn: not reported in source

    Recombinant Lactococcus lactis
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    BPC-157 concentration
    30 ng/ml
    AcmA/Usp45 surface display

    Source sentences

    Summary
    The concentration of BPC-157 delivered by surface display via AcmA/Usp45-fusion was 30 ng/ml.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  3. 04LabNot a test of BPC-157 aloneIn vitro (cells)Other

    In recombinant L. lactis, Usp45 signal-mediated secretion increased the BPC‑157 concentration to 117 ng/ml, the most effective delivery approach.

    In plain wordsIn engineered bacteria, secretion gave 117 ng/ml of BPC‑157, higher than surface display.

    Peptide
    BPC-157
    Outcome
    IncreaseBPC-157 concentration by Usp45-mediated secretion
    Study

    Lactococcus lactisn: not reported in source

    Recombinant Lactococcus lactis
    Comparator
    Surface display via AcmA/Usp45
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    BPC-157 concentration
    117 ng/ml
    Usp45 secretion

    Source sentences

    Summary
    This increased to 117 ng/ml by Usp45 signal-mediated secretion, making the latter the most effective lactococcal delivery approach for BPC-157.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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