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Study · Non-randomized trial · n = 80 · 2019

3 results

Oxytocin administration and emotion recognition abilities in adults with a history of childhood adversity.

Schwaiger M, Heinrichs M, Kumsta R

Psychoneuroendocrinology27 Aug 2018Cited by 24 (Europe PMC)

PMID30189345 (opens in a new tab)DOI10.1016/j.psyneuen.2018.08.025 (opens in a new tab)PepBankPUB-30189345
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy adults with and without childhood adversity, intranasal oxytocin increased accuracy on the Reading the Mind in the Eyes Test versus placebo in the first session.

    In plain wordsIn healthy adults, oxytocin spray improved accuracy in reading emotions from the eyes more than placebo in the first session.

    Peptide
    Oxytocin
    Outcome
    IncreaseRMET accuracy in the first session
    Study

    n = 80

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    both groups profited equally form oxytocin administration and showed greater accuracy under oxytocin compared to placebo in the RMET (p = .049).
    2 context sentences
    Summary · context
    We assessed a total of 80 healthy participants, half with and half without a history of childhood adversity.
    Summary · context
    Participants performed the Reading the Mind in the Eyes Test (RMET) and an emotion recognition task under 24 IU intranasal oxytocin and placebo, using a double-blind crossover study design.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy adults with a history of childhood adversity, intranasal oxytocin improved emotion recognition accuracy versus placebo in the first session, mainly for angry and fearful faces.

    In plain wordsIn healthy adults with childhood adversity, oxytocin spray improved emotion recognition more than placebo in the first session, mainly for angry and fearful faces.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmotion recognition task accuracy in adults with early adversity, first session
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In the emotion recognition task, only the early adversity group benefited significantly from oxytocin administration in the first session (p = .035), mainly due to more accurate recognition of angry and fearful facial expression.
    2 context sentences
    Summary · context
    We assessed a total of 80 healthy participants, half with and half without a history of childhood adversity.
    Summary · context
    Participants performed the Reading the Mind in the Eyes Test (RMET) and an emotion recognition task under 24 IU intranasal oxytocin and placebo, using a double-blind crossover study design.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy adults without a history of childhood adversity, intranasal oxytocin did not significantly improve emotion recognition accuracy versus placebo in the first session.

    In plain wordsIn healthy adults without childhood adversity, oxytocin spray did not significantly improve emotion recognition compared with placebo in the first session.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmotion recognition task accuracy in adults without early adversity, first session
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    only the early adversity group benefited significantly from oxytocin administration in the first session (p = .035), mainly due to more accurate recognition of angry and fearful facial expression.
    2 context sentences
    Summary · context
    We assessed a total of 80 healthy participants, half with and half without a history of childhood adversity.
    Summary · context
    Participants performed the Reading the Mind in the Eyes Test (RMET) and an emotion recognition task under 24 IU intranasal oxytocin and placebo, using a double-blind crossover study design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT03335085

Oxytocin Administration and Emotion Recognition Abilities in Adults Reporting Adverse Childhood Experiences

Ruhr University of Bochumn = 801 Jul 2011 to 5 Nov 2013

Healthy

Trial pageClinicalTrials.govUpdated 7 Nov 2017

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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