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Study · Animal study (in vivo) · rat · 2018

11 results

Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock.

Sims CA, Guan Y, Mukherjee S, Singh K, Botolin P, Davila A Jr, Baur JA

JCI insight6 Sept 2018Cited by 56 (Europe PMC)

PMID30185676 (opens in a new tab)PMCIDPMC6171817 (opens in a new tab)DOI10.1172/jci.insight.120182 (opens in a new tab)PepBankPUB-30185676
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hemorrhagic shock, NMN significantly reduced lactic acidosis.

    In plain wordsIn rats with severe blood loss, NMN reduced lactic acidosis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLactic acidosis
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a rodent model of decompensated hemorrhagic shock, rats receiving NMN displayed significantly reduced lactic acidosis and serum IL-6 levels, two strong predictors of mortality in human patients.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with hemorrhagic shock, NMN significantly reduced serum IL-6.

    In plain wordsIn rats with severe blood loss, NMN reduced the inflammatory marker IL-6.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSerum IL-6
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a rodent model of decompensated hemorrhagic shock, rats receiving NMN displayed significantly reduced lactic acidosis and serum IL-6 levels, two strong predictors of mortality in human patients.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with hemorrhagic shock, NMN increased liver NAD levels.

    In plain wordsIn rats with severe blood loss, NMN increased liver NAD levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLiver NAD
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both livers and kidneys, NMN increased NAD levels and prevented mitochondrial dysfunction.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with hemorrhagic shock, NMN increased kidney NAD levels.

    In plain wordsIn rats with severe blood loss, NMN increased kidney NAD levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseKidney NAD
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both livers and kidneys, NMN increased NAD levels and prevented mitochondrial dysfunction.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hemorrhagic shock, NMN prevented liver mitochondrial dysfunction.

    In plain wordsIn rats with severe blood loss, NMN prevented impaired liver mitochondrial function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLiver mitochondrial dysfunction
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both livers and kidneys, NMN increased NAD levels and prevented mitochondrial dysfunction.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with hemorrhagic shock, NMN prevented kidney mitochondrial dysfunction.

    In plain wordsIn rats with severe blood loss, NMN prevented impaired kidney mitochondrial function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseKidney mitochondrial dysfunction
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both livers and kidneys, NMN increased NAD levels and prevented mitochondrial dysfunction.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, NMN prevented kidney ATP loss following shock and resuscitation.

    In plain wordsIn rats, NMN prevented kidney ATP loss after shock and resuscitation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseKidney ATP loss
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In kidneys, but not in livers, NMN was sufficient to prevent ATP loss following shock and resuscitation.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, NMN did not prevent liver ATP loss following shock and resuscitation.

    In plain wordsIn rats, NMN did not prevent liver ATP loss after shock and resuscitation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeLiver ATP loss
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In kidneys, but not in livers, NMN was sufficient to prevent ATP loss following shock and resuscitation.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, NMN increased time tolerating severe shock before resuscitation by nearly 25%.

    In plain wordsIn rats, NMN increased time tolerating severe shock before resuscitation by nearly 25%.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseTime before resuscitation required
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Intensive care and hospital outcomes · Whole body
    Studied dose
    Dose not stated

    Measurements

    Increase in time before resuscitation
    ≈ 25%
    severe shock

    Source sentences

    Summary
    Overall, NMN increased the time animals could sustain severe shock before requiring resuscitation by nearly 25% and significantly improved survival after resuscitation (P = 0.018), whether NMN was given as a pretreatment or only as an adjunct during resuscitation.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, NMN significantly improved survival after resuscitation when given before shock or during resuscitation.

    In plain wordsIn rats, NMN improved survival after resuscitation when given before shock or during resuscitation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSurvival after resuscitation
    Study

    ratn: not reported in source

    Decompensated hemorrhagic shock
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Overall, NMN increased the time animals could sustain severe shock before requiring resuscitation by nearly 25% and significantly improved survival after resuscitation (P = 0.018), whether NMN was given as a pretreatment or only as an adjunct during resuscitation.
  11. 11LabIn vitro (cells)Efficacy outcome

    In isolated hepatocytes exposed to proinflammatory cytokines, NMN preserved mitochondrial function.

    In plain wordsIn cells exposed to inflammatory cytokines, NMN preserved liver cell mitochondrial function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableHepatocyte mitochondrial function
    Study

    n: not reported in source

    Isolated hepatocytes cocultured with proinflammatory cytokines
    Outcome group
    Mitochondrial function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, NMN preserved mitochondrial function in isolated hepatocytes cocultured with proinflammatory cytokines, indicating a cell-autonomous protective effect that is independent from the reduction in circulating IL-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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