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Study · Not a test of the peptide alone · 2018

2 results

A stable meta-carborane enables the generation of boron-rich peptide agonists targeting the ghrelin receptor.

Worm DJ, Els-Heindl S, Kellert M, Kuhnert R, Saretz S, Koebberling J, Riedl B, Hey-Hawkins E, Beck-Sickinger AG

Journal of peptide science : an official publication of the European Peptide Society31 Aug 2018Cited by 29 (Europe PMC)

PMID30168238 (opens in a new tab)DOI10.1002/psc.3119 (opens in a new tab)PepBankPUB-30168238
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01LabNot a test of Ipamorelin aloneIn vitro (cells)Activity measurement

    Boron-loaded conjugates built on the backbone of ipamorelin were highly potent at the ghrelin receptor.

    In plain wordsIn lab tests, boron-loaded versions built on ipamorelin strongly activated the ghrelin receptor.

    Peptide
    Ipamorelin
    Outcome
    Not applicableGhrelin receptor activation by boron-loaded ipamorelin-based conjugates
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The versatility of this carborane for the development of peptidic boron delivery agents was further demonstrated by the generation of highly potent, boron-loaded conjugates using the backbone of the known ghrelin receptor ligands growth hormone releasing peptide 6 and Ipamorelin.
    1 context sentence
    Summary · context
    We designed a novel hexapeptide super-agonist that was modified with different specifically synthesized carborane monoclusters and tested for ghrelin receptor activation.

    In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cells)Activity measurement

    Boron-loaded carborane conjugates built on the GHRP‑6 backbone were described as highly potent ghrelin receptor ligands.

    In plain wordsIn lab tests, boron-carrying peptides built on a GHRP‑6 backbone were highly potent at the ghrelin receptor.

    Peptide
    GHRP-6
    Outcome
    Not applicableGhrelin receptor activation by boron-loaded conjugates on GHRP-6 backbone
    Study

    n: not reported in source

    Ghrelin receptor activation assay
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    The versatility of this carborane for the development of peptidic boron delivery agents was further demonstrated by the generation of highly potent, boron-loaded conjugates using the backbone of the known ghrelin receptor ligands growth hormone releasing peptide 6 and Ipamorelin.
    1 context sentence
    Summary · context
    We designed a novel hexapeptide super-agonist that was modified with different specifically synthesized carborane monoclusters and tested for ghrelin receptor activation.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 36Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 34 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Version 2

    9 Oct 2026, 03:13 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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