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Study · Animal study (in vivo) · mouse · 2018

3 results

Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease.

Bermúdez ML, Skelton MR, Genter MB

Molecular genetics and metabolism10 Aug 2018Cited by 21 (Europe PMC)

PMID30146452 (opens in a new tab)DOI10.1016/j.ymgme.2018.08.002 (opens in a new tab)PepBankPUB-30146452
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Thy1-aSyn mice, intranasal carnosine attenuated transcriptional deficiencies associated with alpha-synuclein overexpression.

    In plain wordsIn mice with alpha-synuclein overexpression, intranasal carnosine reduced associated gene-expression deficiencies.

    Peptide
    L-carnosine
    Outcome
    DecreaseTranscriptional deficiencies
    Study

    micen: not reported in source

    Thy1-aSyn mouse model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · two monthsAs given in this study (mice).

    Source sentences

    Summary
    These deficiencies were attenuated by IN carnosine administration, which increased the expression of mitochondrial genes and enhanced mitochondrial function.
    3 context sentences
    Summary · context
    Transcriptional deficiencies associated with the aSyn overexpression in Thy1-aSyn mice were related to ribosomal and mitochondrial function.
    Summary · context
    Two-month old Thy1-aSyn mice and wild-type littermates were randomly assigned to treatment groups with intranasal (IN) and drinking water carnosine, with controls receiving 10 μl of sterile waster intranasally or carnosine-free drinking water, respectively.
    Summary · context
    After two months of treatment, mice were euthanized, and the midbrain was dissected for the evaluation of the gene expression and mitochondrial function.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Thy1-aSyn mice, intranasal carnosine increased mitochondrial gene expression.

    In plain wordsIn mice with alpha-synuclein overexpression, intranasal carnosine increased mitochondrial gene expression.

    Peptide
    L-carnosine
    Outcome
    IncreaseMitochondrial gene expression
    Study

    micen: not reported in source

    Thy1-aSyn mouse model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · two monthsAs given in this study (mice).

    Source sentences

    Summary
    These deficiencies were attenuated by IN carnosine administration, which increased the expression of mitochondrial genes and enhanced mitochondrial function.
    2 context sentences
    Summary · context
    Two-month old Thy1-aSyn mice and wild-type littermates were randomly assigned to treatment groups with intranasal (IN) and drinking water carnosine, with controls receiving 10 μl of sterile waster intranasally or carnosine-free drinking water, respectively.
    Summary · context
    After two months of treatment, mice were euthanized, and the midbrain was dissected for the evaluation of the gene expression and mitochondrial function.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Thy1-aSyn mice, intranasal carnosine enhanced mitochondrial function.

    In plain wordsIn mice with alpha-synuclein overexpression, intranasal carnosine improved mitochondrial function.

    Peptide
    L-carnosine
    Outcome
    IncreaseMitochondrial function
    Study

    micen: not reported in source

    Thy1-aSyn mouse model
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    Dose not stated · intranasal · two monthsAs given in this study (mice).

    Source sentences

    Summary
    These deficiencies were attenuated by IN carnosine administration, which increased the expression of mitochondrial genes and enhanced mitochondrial function.
    2 context sentences
    Summary · context
    Two-month old Thy1-aSyn mice and wild-type littermates were randomly assigned to treatment groups with intranasal (IN) and drinking water carnosine, with controls receiving 10 μl of sterile waster intranasally or carnosine-free drinking water, respectively.
    Summary · context
    After two months of treatment, mice were euthanized, and the midbrain was dissected for the evaluation of the gene expression and mitochondrial function.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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