Glycine-modified growth hormone secretagogues identified in seized doping material.

Gajda PM, Holm NB, Hoej LJ, Rasmussen BS, Dalsgaard PW, Reitzel LA, Linnet K

Drug testing and analysis11 Sept 2018Cited by 5 (Europe PMC)

PMID30136411DOI10.1002/dta.2489PepBankPUB-30136411

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

01LabNot a test of GHRP-6 aloneIn vitro (cell-free)Other
LC-HRMS comparison with reference standards identified powders seized by Danish customs as analogs of GHRP‑6 and other secretagogues, each with an extra N-terminal glycine.
In plain wordsLab analysis of seized powders found GHRP‑6 analogs carrying one extra glycine at one end.
Peptide
GHRP-6
Outcome
Not applicableGlycine-modified GHRP-6 analog in seized powders
Study
n: not reported in source
Seized powders analysed by LC-HRMS
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1-29), which can be used as performance-enhancing substances in sports.
1 context sentence(design, population, supporting numbers)
Summary · context
In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-3013641103
02LabNot a test of GHRP-2 aloneIn vitro (cell-free)Other
LC-HRMS comparison with reference standards identified seized powders as analogs of growth hormone secretagogues, including GHRP‑2.
In plain wordsIn lab tests, seized powders were found to contain altered versions of GHRP‑2 and other growth hormone-releasing peptides.
Peptide
GHRP-2
Outcome
Not applicableIdentity of seized powders
Study
n: not reported in source
seized powders
Outcome group
Analytical methods and detection · Pharmacology
Source sentences
Summary
Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1-29), which can be used as performance-enhancing substances in sports.
1 context sentence(design, population, supporting numbers)
Summary · context
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-3013641104
03LabNot a test of GHRP-2 aloneIn vitro (cell-free)Other
In all seized powders, the detected modification was an extra glycine amino acid at the N-terminus, including the GHRP‑2 analog.
In plain wordsIn lab tests, the seized GHRP‑2 powder had an extra glycine added at one end of the peptide.
Peptide
GHRP-2
Outcome
Not applicableType of modification in seized powders
Study
n: not reported in source
seized powders
Outcome group
Analytical methods and detection · Pharmacology
Source sentences
Summary
In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
1 context sentence(design, population, supporting numbers)
Summary · context
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-3013641105
04LabNot a test of Ipamorelin aloneOther designOther
LC-HRMS comparison with reference standards identified the content of seized powders as analogs of growth hormone secretagogues, including ipamorelin.
In plain wordsIn lab tests, seized powders were found to contain analogs of ipamorelin and other growth hormone secretagogues.
Peptide
Ipamorelin
Outcome
Not applicableIdentification of ipamorelin analog in seized preparations
Study
n: not reported in source
Outcome group
Analytical methods and detection · Pharmacology
Source sentences
Summary
Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin
1 context sentence(design, population, supporting numbers)
Summary · context
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-3013641101
05LabNot a test of Ipamorelin aloneOther designOther
In all seized preparations, including the ipamorelin analog, the detected modification was an extra glycine at the N-terminus.
In plain wordsIn lab tests, the seized ipamorelin analog and the other analogs carried one extra glycine at the start of the peptide chain.
Peptide
Ipamorelin
Outcome
Not applicableN-terminal glycine modification of seized secretagogue analogs
Study
n: not reported in source
Outcome group
Analytical methods and detection · Pharmacology
Source sentences
Summary
In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
1 context sentence(design, population, supporting numbers)
Summary · context
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis.
In this study, Ipamorelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Ipamorelin.
Report a problemFND-3013641102

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 29 to 46Current
28 Oct 2026, 02:02 UTC
The same notice was added 18 times, first on 14 Oct 2026, 05:01 UTC. The status did not change between them.
Study results updated
Version 28
14 Oct 2026, 01:46 UTC
Study data updated · source update from Europe PMC
Versions 22 to 27
13 Oct 2026, 21:46 UTC
The same notice was added 6 times, first on 13 Oct 2026, 21:43 UTC. The status did not change between them.
Study results updated
Version 21
13 Oct 2026, 16:31 UTC
Study data updated · source update from Europe PMC
Versions 3 to 20
13 Oct 2026, 14:22 UTC
The same notice was added 18 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.
Study results updated
Version 2
9 Oct 2026, 03:13 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

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