[Study of the neuroprotective effects of carnosine in an experimental model of focal cerebral ischemia/reperfusion].

Devyatov AA, Fedorova TN, Stvolinsky SL, Ryzhkov IN, Riger NA, Tutelyan VA

Biomeditsinskaia khimiia1 Aug 2018Cited by 3 (Europe PMC)

PMID30135281DOI10.18097/pbmc20186404344PepBankPUB-30135281

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, dietary carnosine significantly reduced infarct size.
In plain wordsIn rats with cerebral ischemia/reperfusion, dietary carnosine significantly reduced infarct size.
Peptide
L-carnosine
Outcome
DecreaseInfarct size
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Carnosine significantly reduced the infarct size.
2 context sentences(design, population, supporting numbers)
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528101
02AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine increased brain total antioxidant capacity.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine increased brain antioxidant capacity.
Peptide
L-carnosine
Outcome
IncreaseTotal antioxidant capacity
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Carnosine also increased TAC and reduced the level of MDA and isoprostanes in brain tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528102
03AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine reduced brain malondialdehyde.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine reduced brain malondialdehyde.
Peptide
L-carnosine
Outcome
DecreaseMalondialdehyde
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Carnosine also increased TAC and reduced the level of MDA and isoprostanes in brain tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528103
04AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine reduced brain isoprostanes.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine reduced brain isoprostanes.
Peptide
L-carnosine
Outcome
DecreaseIsoprostanes
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Carnosine also increased TAC and reduced the level of MDA and isoprostanes in brain tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528104
05AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain protein carbonyls.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain protein carbonyls.
Peptide
L-carnosine
Outcome
No significant changeProtein carbonyls
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Influence of carnosine on other parameters was not detected.
3 context sentences(design, population, supporting numbers)
Summary · context
In brain tissue of animals the content of malondialdehyde (MDA), protein carbonyls (PC), total antioxidant capacity (TAC), total activity of superoxide dismutase (SOD), glutathione peroxidase (GP), catalase (CAT) and glutathione transferase (GT), content of isoprostanes and cytokines were measured.
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528105
06AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain superoxide dismutase activity.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain superoxide dismutase activity.
Peptide
L-carnosine
Outcome
No significant changeSuperoxide dismutase activity
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Influence of carnosine on other parameters was not detected.
3 context sentences(design, population, supporting numbers)
Summary · context
In brain tissue of animals the content of malondialdehyde (MDA), protein carbonyls (PC), total antioxidant capacity (TAC), total activity of superoxide dismutase (SOD), glutathione peroxidase (GP), catalase (CAT) and glutathione transferase (GT), content of isoprostanes and cytokines were measured.
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528106
07AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain glutathione peroxidase activity.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain glutathione peroxidase activity.
Peptide
L-carnosine
Outcome
No significant changeGlutathione peroxidase activity
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Influence of carnosine on other parameters was not detected.
3 context sentences(design, population, supporting numbers)
Summary · context
In brain tissue of animals the content of malondialdehyde (MDA), protein carbonyls (PC), total antioxidant capacity (TAC), total activity of superoxide dismutase (SOD), glutathione peroxidase (GP), catalase (CAT) and glutathione transferase (GT), content of isoprostanes and cytokines were measured.
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528107
08AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain catalase activity.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain catalase activity.
Peptide
L-carnosine
Outcome
No significant changeCatalase activity
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Influence of carnosine on other parameters was not detected.
3 context sentences(design, population, supporting numbers)
Summary · context
In brain tissue of animals the content of malondialdehyde (MDA), protein carbonyls (PC), total antioxidant capacity (TAC), total activity of superoxide dismutase (SOD), glutathione peroxidase (GP), catalase (CAT) and glutathione transferase (GT), content of isoprostanes and cytokines were measured.
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528108
09AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain glutathione transferase activity.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain glutathione transferase activity.
Peptide
L-carnosine
Outcome
No significant changeGlutathione transferase activity
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Influence of carnosine on other parameters was not detected.
3 context sentences(design, population, supporting numbers)
Summary · context
In brain tissue of animals the content of malondialdehyde (MDA), protein carbonyls (PC), total antioxidant capacity (TAC), total activity of superoxide dismutase (SOD), glutathione peroxidase (GP), catalase (CAT) and glutathione transferase (GT), content of isoprostanes and cytokines were measured.
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528109
10AnimalAnimal study (in vivo)Efficacy outcome
In Wistar rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain cytokines.
In plain wordsIn rats with cerebral ischemia/reperfusion, carnosine had no detected effect on brain cytokines.
Peptide
L-carnosine
Outcome
No significant changeCytokines
Study
Wistar ratsn: not reported in source
Focal cerebral ischemia/reperfusion
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
150 mg/kg daily · dietary · 7 days before ischemiaAs given in this study (Wistar rats).
Source sentences
Summary
Influence of carnosine on other parameters was not detected.
3 context sentences(design, population, supporting numbers)
Summary · context
In brain tissue of animals the content of malondialdehyde (MDA), protein carbonyls (PC), total antioxidant capacity (TAC), total activity of superoxide dismutase (SOD), glutathione peroxidase (GP), catalase (CAT) and glutathione transferase (GT), content of isoprostanes and cytokines were measured.
Summary · context
The neuroprotective effect of dietary carnosine administration was investigated in an experimental model of focal cerebral ischemia/reperfusion in Wistar rats.
Summary · context
Animals received carnosine with a diet at a daily dose of 150 mg/kg for 7 days before temporary occlusion of the middle cerebral artery (MCA), performed for 60 min.
Report a problemFND-3013528110

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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