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Study · In vitro (cells) · 2018

2 results

Melanocortin-4 receptor in swamp eel (Monopterus albus): Cloning, tissue distribution, and pharmacology.

Yi TL, Yang LK, Ruan GL, Yang DQ, Tao YX

Gene1 Aug 2018Cited by 28 (Europe PMC)

PMID30075196 (opens in a new tab)DOI10.1016/j.gene.2018.07.056 (opens in a new tab)PepBankPUB-30075196
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In receptor assays, NDP-MSH bound to swamp eel MC4R (maMC4R).

    In plain wordsIn lab tests, NDP-MSH bound to the swamp eel melanocortin-4 receptor.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableBinding of NDP-MSH to swamp eel MC4R
    Study

    n: not reported in source

    Swamp eel MC4R (maMC4R) functional assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Four agonists, α-melanocyte stimulating hormone (α-MSH), β-MSH, [Nle4, D-Phe7]-α-MSH (NDP-MSH), and adrenocorticotropin, could bind to maMC4R
    1 context sentence
    Summary · context
    The maMC4R was further demonstrated to be a functional receptor by pharmacological studies.
  2. 02LabIn vitro (cells)Activity measurement

    In receptor assays, NDP-MSH induced intracellular cAMP production dose-dependently through swamp eel MC4R.

    In plain wordsIn lab tests, NDP-MSH raised cAMP in cells carrying the swamp eel receptor, and more NDP-MSH gave a bigger rise.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasecAMP production induced by NDP-MSH
    Study

    n: not reported in source

    Swamp eel MC4R (maMC4R) functional assays
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Four agonists, α-melanocyte stimulating hormone (α-MSH), β-MSH, [Nle4, D-Phe7]-α-MSH (NDP-MSH), and adrenocorticotropin, could bind to maMC4R and induce intracellular cAMP production dose-dependently.
    1 context sentence
    Summary · context
    The maMC4R was further demonstrated to be a functional receptor by pharmacological studies.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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