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Study · Animal study (in vivo) · cattle · 2018

7 results

Effect of Kisspeptin-10 on plasma luteinizing hormone concentrations and follicular dynamics during the luteal phase in cattle.

Leonardi CEP, Dias FCF, Adams GP, Singh J

Theriogenology26 Jun 2018Cited by 7 (Europe PMC)

PMID30071491 (opens in a new tab)DOI10.1016/j.theriogenology.2018.06.023 (opens in a new tab)PepBankPUB-30071491
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase heifers, the LH peak after intravenous Kisspeptin‑10 was lower than after GnRH; the GnRH peak was 3.5-fold higher.

    In plain wordsIn cattle, kisspeptin‑10 into a vein gave a much lower LH peak than GnRH.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePeak plasma LH, Kp iv versus GnRH
    Study

    cattlen = 15

    Luteal-phase heifers (Expt 1)
    Comparator
    GnRH 100 μg im
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg · intravenousAs given in this study (cattle).

    Measurements

    LH peak, GnRH relative to Kp iv
    3.5 fold
    GnRH group versus Kp iv group

    Source sentences

    Summary
    The LH peak was 3.5-folds higher in the GnRH group than the Kp iv group (P < 0.0001).
    1 context sentence
    Summary · context
    Heifers were treated on Day 10 (4 days after wave emergence) with 100 μg GnRH im (n = 9), 2 mL saline im (n = 7), 1 mg Kisspeptin-10 im (Kp im, n = 6) or 1 mg Kisspeptin-10 iv (Kp iv; n = 6).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase beef cows, the dominant follicle was larger 12-48 hours after Kisspeptin‑10 (groups combined) than after saline.

    In plain wordsIn cows, the main follicle was bigger after kisspeptin‑10 than after saline.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseDominant follicle diameter 12-48 h after treatment
    Study

    cattlen = 15

    Luteal-phase non-lactating beef cows (Expt 2)
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 or 15 mg · intravenousAs given in this study (cattle).

    Source sentences

    Summary
    The diameter of the dominant follicle was greater (P = 0.02) at 12-48 h after kisspeptin treatment (Kp groups combined) than the Saline group in Expt 2.
    1 context sentence
    Summary · context
    In Experiment 2, non-lactating beef cows on Day 5 were treated with 100 μg GnRH im (n = 9), saline im (n = 5), 10 mg of Kisspeptin-10 iv (Kp 10 mg; n = 5) or 15 mg of Kisspeptin-10 iv (Kp 15 mg; n = 5).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase heifers, the peak plasma LH concentration was higher after intravenous than after intramuscular Kisspeptin‑10.

    In plain wordsIn cattle, kisspeptin‑10 into a vein gave a higher LH peak than kisspeptin‑10 into a muscle.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePeak plasma LH, iv versus im Kisspeptin-10
    Study

    cattlen = 12

    Luteal-phase heifers (Expt 1)
    Comparator
    Kisspeptin-10 1 mg im
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg · intravenousAs given in this study (cattle).

    Source sentences

    Summary
    The peak concentration occurred at 15 min and was higher in the Kp iv group than in the Kp im group (P = 0.01).
    1 context sentence
    Summary · context
    Heifers were treated on Day 10 (4 days after wave emergence) with 100 μg GnRH im (n = 9), 2 mL saline im (n = 7), 1 mg Kisspeptin-10 im (Kp im, n = 6) or 1 mg Kisspeptin-10 iv (Kp iv; n = 6).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase beef cows, Kisspeptin‑10 15 mg induced higher plasma LH concentrations than 10 mg at the peak, 30 and 60 minutes.

    In plain wordsIn cows, the 15 mg dose of kisspeptin‑10 gave higher LH than the 10 mg dose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH, Kp 15 mg versus Kp 10 mg
    Study

    cattlen = 10

    Luteal-phase non-lactating beef cows (Expt 2)
    Comparator
    Kisspeptin-10 10 mg iv
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    15 mg · intravenousAs given in this study (cattle).

    Source sentences

    Summary
    Kp 15 mg at peak (15min), 30 and 60 min induced higher (P < 0.0001) plasma LH concentrations than Kp 10 mg and saline.
    1 context sentence
    Summary · context
    In Experiment 2, non-lactating beef cows on Day 5 were treated with 100 μg GnRH im (n = 9), saline im (n = 5), 10 mg of Kisspeptin-10 iv (Kp 10 mg; n = 5) or 15 mg of Kisspeptin-10 iv (Kp 15 mg; n = 5).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase beef cows, Kisspeptin‑10 15 mg induced higher plasma LH concentrations than saline at the peak, 30 and 60 minutes.

    In plain wordsIn cows, the 15 mg dose of kisspeptin‑10 raised LH more than saline.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH, Kp 15 mg versus saline
    Study

    cattlen = 10

    Luteal-phase non-lactating beef cows (Expt 2)
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    15 mg · intravenousAs given in this study (cattle).

    Source sentences

    Summary
    Kp 15 mg at peak (15min), 30 and 60 min induced higher (P < 0.0001) plasma LH concentrations than Kp 10 mg and saline.
    1 context sentence
    Summary · context
    In Experiment 2, non-lactating beef cows on Day 5 were treated with 100 μg GnRH im (n = 9), saline im (n = 5), 10 mg of Kisspeptin-10 iv (Kp 10 mg; n = 5) or 15 mg of Kisspeptin-10 iv (Kp 15 mg; n = 5).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase heifers, intravenous Kisspeptin‑10 increased plasma LH concentrations for 1 hour.

    In plain wordsIn cattle, kisspeptin‑10 given into a vein raised blood LH for about an hour.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH after Kp iv, Expt 1
    Study

    cattlen = 6

    Luteal-phase heifers (Expt 1)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg · intravenousAs given in this study (cattle).

    Source sentences

    Summary
    In Expt 1, plasma LH concentrations increased for 1 h following Kp iv administration.
    1 context sentence
    Summary · context
    Heifers were treated on Day 10 (4 days after wave emergence) with 100 μg GnRH im (n = 9), 2 mL saline im (n = 7), 1 mg Kisspeptin-10 im (Kp im, n = 6) or 1 mg Kisspeptin-10 iv (Kp iv; n = 6).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In luteal-phase cattle, Kisspeptin‑10 did not induce ovulation in either experiment, while GnRH did.

    In plain wordsIn cattle, kisspeptin‑10 did not trigger ovulation, while GnRH did.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeOvulation
    Study

    cattlen: not reported in source

    Luteal-phase heifers and beef cows
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg (Expt 1); 10 or 15 mg (Expt 2) · intramuscular or intravenousAs given in this study (cattle).

    Source sentences

    Summary
    Kisspeptin-treated animals did not ovulate in either experiment while GnRH induced ovulation (n = 5/9 in Expt 1; 9/9 in Expt 2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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