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Study · Systematic review · n = 941 · 2018

3 results

Pharmacologic therapy to induce weight loss in women who have obesity/overweight with polycystic ovary syndrome: a systematic review and network meta-analysis.

Wang FF, Wu Y, Zhu YH, Ding T, Batterham RL, Qu F, Hardiman PJ

Obesity reviews : an official journal of the International Association for the Study of Obesity31 Jul 2018Cited by 55 (Europe PMC)

PMID30066361 (opens in a new tab)DOI10.1111/obr.12720 (opens in a new tab)PepBankPUB-30066361
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In women with PCOS and overweight or obesity, a network meta-analysis found that liraglutide gave the greatest weight loss, ahead of orlistat and metformin.

    In plain wordsIn women with PCOS and excess weight, pooled trials showed more weight loss with liraglutide than with orlistat or metformin.

    Peptide
    Liraglutide
    Outcome
    DecreaseWeight loss ranking
    Study

    n = 941

    Comparator
    Orlistat and metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The amount of weight lost differed significantly among the drugs (in descending order): liraglutide, orlistat and metformin.
    2 context sentences
    Summary · context
    Individually randomized, parallel group trials that evaluated the effects of these pharmacological treatments among adults or adolescents with PCOS and overweight/obesity, compared with a placebo or metformin group, were considered eligible.
    Summary · context
    Twenty-three trials reporting on 941 women were included in the network meta-analysis.
  2. 02HumanSystematic reviewEfficacy outcome

    In women with PCOS and overweight or obesity, a network meta-analysis found that liraglutide alone significantly reduced waist circumference.

    In plain wordsIn women with PCOS and excess weight, pooled trials showed that liraglutide alone reduced waist size.

    Peptide
    Liraglutide
    Outcome
    DecreaseWaist circumference
    Study

    n: not reported in source

    Comparator
    Placebo or metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Liraglutide alone, liraglutide/metformin and metformin alone significantly reduced waist circumference, but no change was found with orlistat.
    2 context sentences
    Summary · context
    Individually randomized, parallel group trials that evaluated the effects of these pharmacological treatments among adults or adolescents with PCOS and overweight/obesity, compared with a placebo or metformin group, were considered eligible.
    Summary · context
    Twenty-three trials reporting on 941 women were included in the network meta-analysis.

Studies that did not test the peptide alone1

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

  1. 03HumanNot a test of Liraglutide aloneSystematic reviewEfficacy outcome

    In women with PCOS and overweight or obesity, a network meta-analysis found that liraglutide combined with metformin significantly reduced waist circumference.

    In plain wordsIn women with PCOS and excess weight, pooled trials showed that liraglutide together with metformin reduced waist size.

    Peptide
    Liraglutide
    Outcome
    DecreaseWaist circumference with liraglutide plus metformin
    Study

    n: not reported in source

    Comparator
    Placebo or metformin
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    Liraglutide alone, liraglutide/metformin and metformin alone significantly reduced waist circumference, but no change was found with orlistat.
    2 context sentences
    Summary · context
    Individually randomized, parallel group trials that evaluated the effects of these pharmacological treatments among adults or adolescents with PCOS and overweight/obesity, compared with a placebo or metformin group, were considered eligible.
    Summary · context
    Twenty-three trials reporting on 941 women were included in the network meta-analysis.

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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