Skip to content

Study · Animal study (in vivo) · rat · 2018

4 results

Neuroprotective effect of glucagon-like peptide-1 receptor agonist is independent of glycaemia normalization in type two diabetic rats.

Filchenko I, Simanenkova A, Chefu S, Kolpakova M, Vlasov T

Diabetes & vascular disease research19 Jul 2018Cited by 23 (Europe PMC)

PMID30024276 (opens in a new tab)DOI10.1177/1479164118788079 (opens in a new tab)PepBankPUB-30024276
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In non-diabetic rats with transient focal brain ischaemia, liraglutide pretreatment reduced infarct size compared with vehicle controls.

    In plain wordsIn non-diabetic rats, liraglutide given before a stroke-like injury reduced brain damage compared with vehicle.

    Peptide
    Liraglutide
    Outcome
    DecreaseBrain infarct volume (non-diabetic rats)
    Study

    ratn: not reported in source

    Non-diabetic male Wistar rats with transient focal brain ischaemia
    Comparator
    Vehicle-treated controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with liraglutide in diabetic and non-diabetic animals reduced infarct size as compared to controls, while only non-diabetic liraglutide-treated rats presented neurologic deficit decreases.
    1 context sentence
    Summary · context
    This two-phase study used male Wistar rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with type 2 diabetes and transient focal brain ischaemia, liraglutide pretreatment reduced infarct size compared with vehicle controls.

    In plain wordsIn diabetic rats, liraglutide given before a stroke-like injury reduced brain damage compared with vehicle.

    Peptide
    Liraglutide
    Outcome
    DecreaseBrain infarct volume (diabetic rats)
    Study

    ratn: not reported in source

    Male Wistar rats with type 2 diabetes and transient focal brain ischaemia
    Comparator
    Vehicle-treated controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with liraglutide in diabetic and non-diabetic animals reduced infarct size as compared to controls, while only non-diabetic liraglutide-treated rats presented neurologic deficit decreases.
    1 context sentence
    Summary · context
    This two-phase study used male Wistar rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In non-diabetic rats with transient focal brain ischaemia, liraglutide pretreatment decreased neurological deficit compared with vehicle controls.

    In plain wordsIn non-diabetic rats, liraglutide given before a stroke-like injury lessened nerve-function problems compared with vehicle.

    Peptide
    Liraglutide
    Outcome
    DecreaseNeurological deficit (non-diabetic rats)
    Study

    ratn: not reported in source

    Non-diabetic male Wistar rats with transient focal brain ischaemia
    Comparator
    Vehicle-treated controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with liraglutide in diabetic and non-diabetic animals reduced infarct size as compared to controls, while only non-diabetic liraglutide-treated rats presented neurologic deficit decreases.
    1 context sentence
    Summary · context
    This two-phase study used male Wistar rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with type 2 diabetes and transient focal brain ischaemia, liraglutide pretreatment did not decrease neurological deficit; only non-diabetic rats showed a decrease.

    In plain wordsIn diabetic rats, liraglutide given before a stroke-like injury did not lessen nerve-function problems compared with vehicle.

    Peptide
    Liraglutide
    Outcome
    No significant changeNeurological deficit (diabetic rats)
    Study

    ratn: not reported in source

    Male Wistar rats with type 2 diabetes and transient focal brain ischaemia
    Comparator
    Vehicle-treated controls
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Pretreatment with liraglutide in diabetic and non-diabetic animals reduced infarct size as compared to controls, while only non-diabetic liraglutide-treated rats presented neurologic deficit decreases.
    1 context sentence
    Summary · context
    This two-phase study used male Wistar rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.