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Study · Not a test of the peptide alone · 2018

2 results

Chimeric Adeno-Associated Virus-Mediated Cardiovascular Reprogramming for Ischemic Heart Disease.

Yoo SY, Jeong SN, Kang JI, Lee SW

ACS omega1 May 2018Cited by 30 (Europe PMC)

PMID30023931 (opens in a new tab)PMCIDPMC6044635 (opens in a new tab)DOI10.1021/acsomega.8b00904 (opens in a new tab)PepBankPUB-30023931
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    A chimeric AAV strategy that combined AAV-GMT reprogramming with AAV-Tβ4 was reported to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts.

    In plain wordsA combined gene treatment, with thymosin beta‑4 as one part, was reported to make new heart muscle cells and limit scar collagen.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedNew cardiomyocytes and collagen deposition with AAV-GMT plus AAV-Tβ4
    Study

    n: not reported in source

    Outcome group
    Heart repair and regeneration · Cardiovascular

    Source sentences

    Summary
    Here, we demonstrated chimeric adeno-associated virus (chimeric AAV), AAV-DJ-mediated cardiovascular reprogramming strategy to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts by inducing synergism of chimeric AAV-expressing Gata4, Mef2c, Tbx5 (AAV-GMT)-mediated heart…

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In the combined AAV-GMT and AAV-Tβ4 strategy, AAV-Tβ4 helped to induce GMT expression.

    In plain wordsIn a combined gene treatment, the thymosin beta‑4 part helped switch on the other reprogramming genes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseGMT expression with AAV-Tβ4
    Study

    n: not reported in source

    Outcome group
    Heart repair and regeneration · Cardiovascular

    Source sentences

    Summary
    here AAV-Tβ4 help to induce GMT expression, providing a chimeric AAV-mediated therapeutic cell reprogramming strategy for ischemic heart diseases.
    1 context sentence
    Summary · context
    Here, we demonstrated chimeric adeno-associated virus (chimeric AAV), AAV-DJ-mediated cardiovascular reprogramming strategy to generate new cardiomyocytes and limit collagen deposition in cardiac fibroblasts by inducing synergism of chimeric AAV-expressing Gata4, Mef2c, Tbx5 (AAV-GMT)-mediated heart…

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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