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Study · Animal study (in vivo) · rat · 2016

5 results

Histopathological and immunohistochemical study of the protective effect of triptorelin on the neurocytes of the hippocampus and the cerebral cortex of male albino rats after short-term exposure to cyclophosphamide.

Shaibah HS, Elsify AK, Medhat TM, Rezk HM, El-Sherbiny M

Journal of microscopy and ultrastructure15 Dec 2015Cited by 14 (Europe PMC)

PMID30023218 (opens in a new tab)PMCIDPMC6014199 (opens in a new tab)DOI10.1016/j.jmau.2015.12.002 (opens in a new tab)PepBankPUB-30023218
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-exposed rats, triptorelin improved histological signs of neural degeneration.

    In plain wordsIn rats exposed to cyclophosphamide, triptorelin reduced signs of nerve cell degeneration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseHistological degeneration
    Study

    ratn: not reported in source

    Male albino rats exposed to cyclophosphamide
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.05 mg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous triptorelin (0.05 mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis.
    1 context sentence
    Summary · context
    In the current study, intraperitoneal cyclophosphamide (65 mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-exposed rats, triptorelin improved histological signs of apoptosis.

    In plain wordsIn rats exposed to cyclophosphamide, triptorelin reduced signs of programmed cell death.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseApoptosis
    Study

    ratn: not reported in source

    Male albino rats exposed to cyclophosphamide
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.05 mg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous triptorelin (0.05 mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis.
    1 context sentence
    Summary · context
    In the current study, intraperitoneal cyclophosphamide (65 mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In triptorelin-treated rats, anti-Bcl2 staining showed an increased apoptotic index in cerebral cortex and hippocampus.

    In plain wordsIn rats, staining for Bcl2 showed an increased cell death index in the brain after triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseAnti-Bcl2 apoptotic index
    Study

    ratn: not reported in source

    Male albino rats exposed to cyclophosphamide
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.05 mg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Anti-Bcl2 staining of sections of the cerebral cortex and hippocampus showed that the apoptotic index was increased.
    2 context sentences
    Summary · context
    Subcutaneous triptorelin (0.05 mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis.
    Summary · context
    In the current study, intraperitoneal cyclophosphamide (65 mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In triptorelin-treated rats, anti-p53 staining showed a decreased apoptotic index.

    In plain wordsIn rats, staining for p53 showed a decreased cell death index after triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseAnti-p53 apoptotic index
    Study

    ratn: not reported in source

    Male albino rats exposed to cyclophosphamide
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.05 mg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    This finding was confirmed by the anti-p53 staining, which showed a significant decrease in the apoptotic index.
    2 context sentences
    Summary · context
    Subcutaneous triptorelin (0.05 mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis.
    Summary · context
    In the current study, intraperitoneal cyclophosphamide (65 mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In cyclophosphamide-exposed rats, triptorelin treatment accompanied significant restoration of normal brain histology.

    In plain wordsIn rats exposed to cyclophosphamide, triptorelin treatment accompanied restoration of normal brain tissue structure.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseNormal brain histology
    Study

    ratn: not reported in source

    Male albino rats exposed to cyclophosphamide
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.05 mg/kg/day · subcutaneous · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Ultimately, such improvements were accompanied by significant restoration of normal brain histology, as revealed by hematoxylin and eosin.
    2 context sentences
    Summary · context
    Subcutaneous triptorelin (0.05 mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis.
    Summary · context
    In the current study, intraperitoneal cyclophosphamide (65 mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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