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Study · Animal study (in vivo) · mouse · 2018

19 results

The Neurovascular Protective Effect of S14G-Humanin in a Murine MCAO Model and Brain Endothelial Cells.

Peng T, Wan W, Wang J, Liu Y, Fu Z, Ma X, Li J, Sun G, Ji Y, Lu J, Lu H, Liu Y

IUBMB life1 Jul 2018Cited by 23 (Europe PMC)

PMID29999240 (opens in a new tab)DOI10.1002/iub.1869 (opens in a new tab)PepBankPUB-29999240
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Jump to 19 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

19 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG ameliorated cerebral infarction.

    In plain wordsIn mice with induced stroke, a humanin analogue reduced brain infarction.

    Peptide
    Humanin
    Outcome
    DecreaseCerebral infarction
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-α, IL-1β, IL-6 and MCP-1 cytokines.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG suppressed the production of TNF-alpha.

    In plain wordsIn mice with induced stroke, a humanin analogue lowered TNF-alpha.

    Peptide
    Humanin
    Outcome
    DecreaseTNF-alpha production
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-α, IL-1β, IL-6 and MCP-1 cytokines.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG suppressed the production of IL-1beta.

    In plain wordsIn mice with induced stroke, a humanin analogue lowered IL-1beta.

    Peptide
    Humanin
    Outcome
    DecreaseIL-1beta production
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-α, IL-1β, IL-6 and MCP-1 cytokines.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG suppressed the production of IL-6.

    In plain wordsIn mice with induced stroke, a humanin analogue lowered IL-6.

    Peptide
    Humanin
    Outcome
    DecreaseIL-6 production
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-α, IL-1β, IL-6 and MCP-1 cytokines.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG suppressed the production of MCP-1.

    In plain wordsIn mice with induced stroke, a humanin analogue lowered MCP-1.

    Peptide
    Humanin
    Outcome
    DecreaseMCP-1 production
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a murine middle cerebral artery occlusion (MCAO) stroke model, HNG ameliorates cerebral infarction and suppresses the production of TNF-α, IL-1β, IL-6 and MCP-1 cytokines.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG inhibited the expression of VCAM-1 in cortex tissue.

    In plain wordsIn mice with induced stroke, a humanin analogue lowered VCAM-1 in the brain cortex.

    Peptide
    Humanin
    Outcome
    DecreaseVCAM-1 expression in cortex
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG inhibits the expression of vascular adhesion molecules such as VCAM-1 and ICAM-1 in the cortex tissue.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse MCAO stroke model, HNG inhibited the expression of ICAM-1 in cortex tissue.

    In plain wordsIn mice with induced stroke, a humanin analogue lowered ICAM-1 in the brain cortex.

    Peptide
    Humanin
    Outcome
    DecreaseICAM-1 expression in cortex
    Study

    mousen: not reported in source

    Middle cerebral artery occlusion stroke model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG inhibits the expression of vascular adhesion molecules such as VCAM-1 and ICAM-1 in the cortex tissue.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  8. 08LabIn vitro (cells)Efficacy outcome

    In mouse brain endothelial bEnd.3 cells, HNG protected cell survival under oxygen deprivation.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue protected survival when oxygen was lacking.

    Peptide
    Humanin
    Outcome
    IncreaseCell survival under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In mouse brain endothelial cells bEnd.3, HNG protects cell survival under oxygen deprivation (OGD) conditions.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  9. 09LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed ROS production induced by oxygen deprivation.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered reactive oxygen production caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseROS production under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  10. 10LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed OGD-induced production of TNF-alpha.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered TNF-alpha caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseTNF-alpha production under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  11. 11LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed OGD-induced production of IL-1beta.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered IL-1beta caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseIL-1beta production under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  12. 12LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed OGD-induced production of IL-6.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered IL-6 caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseIL-6 production under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  13. 13LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed OGD-induced production of MCP-1.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered MCP-1 caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseMCP-1 production under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  14. 14LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed OGD-induced VCAM-1 expression.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered VCAM-1 caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseVCAM-1 expression under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  15. 15LabIn vitro (cells)Efficacy outcome

    In bEnd.3 cells, HNG suppressed OGD-induced ICAM-1 expression.

    In plain wordsIn mouse brain blood-vessel cells, a humanin analogue lowered ICAM-1 caused by low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseICAM-1 expression under OGD
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells under oxygen deprivation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG suppresses ROS production as well as that of the same panel of cytokines and vascular adhesion molecules induced by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  16. 16LabIn vitro (cells)Efficacy outcome

    HNG reduced the number of THP-1 cells attached to bEnd.3 cells after OGD.

    In plain wordsIn cells, a humanin analogue reduced immune cells sticking to brain blood-vessel cells after low oxygen.

    Peptide
    Humanin
    Outcome
    DecreaseTHP-1 cells attached to bEnd.3
    Study

    mousen: not reported in source

    bEnd.3 brain endothelial cells with THP-1 cells
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG also reduces the numbers of THP-1 cells attached to bEnd.3 by OGD.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  17. 17LabIn vitro (cells)Mechanism

    HNG acted through inhibition of the NF-kB pathway factor IKKalpha.

    In plain wordsIn cells, a humanin analogue worked by blocking IKKalpha in the NF-kB pathway.

    Peptide
    Humanin
    Outcome
    DecreaseIKKalpha inhibition
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, we show that HNG exerts its effect via inhibition of the NF- κB pathway factor IKKα, activation of IκBα and accumulation of p65 in the nucleus.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  18. 18LabIn vitro (cells)Mechanism

    HNG acted through activation of IkBalpha in the NF-kB pathway.

    In plain wordsIn cells, a humanin analogue worked by activating IkBalpha in the NF-kB pathway.

    Peptide
    Humanin
    Outcome
    IncreaseIkBalpha activation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, we show that HNG exerts its effect via inhibition of the NF- κB pathway factor IKKα, activation of IκBα and accumulation of p65 in the nucleus.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.
  19. 19LabIn vitro (cells)Mechanism

    HNG acted through accumulation of p65 in the nucleus.

    In plain wordsIn cells, a humanin analogue worked through a build-up of p65 in the cell nucleus.

    Peptide
    Humanin
    Outcome
    IncreaseNuclear p65 accumulation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, we show that HNG exerts its effect via inhibition of the NF- κB pathway factor IKKα, activation of IκBα and accumulation of p65 in the nucleus.
    1 context sentence
    Summary · context
    In this study, we investigated the neuroprotective effects of HNG in vivo and in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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