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Study · Measured the body's own peptide · 2019

4 results

Human Aging and Longevity Are Characterized by High Levels of Mitokines.

Conte M, Ostan R, Fabbri C, Santoro A, Guidarelli G, Vitale G, Mari D, Sevini F, Capri M, Sandri M, Monti D, Franceschi C, Salvioli S

The journals of gerontology. Series A, Biological sciences and medical sciences1 Apr 2019Cited by 163 (Europe PMC)

PMID29955888 (opens in a new tab)DOI10.1093/gerona/gly153 (opens in a new tab)PepBankPUB-29955888
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In 693 people aged 21 to 113 years, plasma levels of the body's own humanin were increased in old age, with the highest levels in centenarians.

    In plain wordsIn people aged 21 to 113, the body's own humanin levels were higher in old age and highest in centenarians.

    Peptide
    Humanin
    Outcome
    IncreasePlasma humanin by age
    Study

    n = 693

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    FGF21, HN, and GDF15 resulted increased in old age, with the highest levels found in centenarians.
    1 context sentence
    Summary · context
    We analyzed FGF21, HN, and GDF15 plasma levels in 693 subjects aged from 21 to 113 years, and the association of these mitokines with parameters of health status.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In 693 people aged 21 to 113 years, higher plasma levels of the mitokines (FGF21, HN, GDF15) were associated with worsened parameters such as handgrip strength, insulin sensitivity and triglycerides, particularly in 70-year-old persons.

    In plain wordsHigher levels of the body's own humanin and two related molecules were linked to worse health measures, mostly at age 70.

    Peptide
    Humanin
    Outcome
    Not applicableMitokines and health parameters
    Study

    n = 693

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    These molecules are associated with worsened parameters (such as handgrip strength, insulin sensitivity, triglycerides), particularly in 70-year-old persons
    1 context sentence
    Summary · context
    We analyzed FGF21, HN, and GDF15 plasma levels in 693 subjects aged from 21 to 113 years, and the association of these mitokines with parameters of health status.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In the oldest subjects, plasma levels of the mitokines (FGF21, HN, GDF15) were inversely correlated with survival.

    In plain wordsIn the oldest people, higher levels of the body's own humanin and two related molecules were linked to shorter survival.

    Peptide
    Humanin
    Outcome
    Not applicableMitokine levels and survival in the oldest subjects
    Study

    n = 693

    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    their levels are inversely correlated with survival in the oldest subjects
    1 context sentence
    Summary · context
    We analyzed FGF21, HN, and GDF15 plasma levels in 693 subjects aged from 21 to 113 years, and the association of these mitokines with parameters of health status.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Persons with Down syndrome had higher levels of the body's own humanin than their siblings.

    In plain wordsPeople with Down syndrome had higher levels of the body's own humanin than their siblings.

    Peptide
    Humanin
    Outcome
    IncreaseHumanin in Down syndrome
    Study

    n: not reported in source

    Comparator
    siblings
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    persons with Down Syndrome (characterized by accelerated aging) have higher levels of GDF15 and HN with respect to their siblings

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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