Impact of Perfluorooctane Sulfonate on Reproductive Ability of Female Mice through Suppression of Estrogen Receptor α-Activated Kisspeptin Neurons.

Wang X, Bai Y, Tang C, Cao X, Chang F, Chen L

Toxicological sciences : an official journal of the Society of Toxicology1 Oct 2018Cited by 47 (Europe PMC)

PMID29939337DOI10.1093/toxsci/kfy167PepBankPUB-29939337

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In female mice exposed to PFOS, the GPR54 agonist kisspeptin‑10 corrected the prolongation of diestrus.
In plain wordsIn mice exposed to a pollutant, kisspeptin‑10 corrected the longer resting phase of the cycle.
Peptide
Kisspeptin-10
Outcome
DecreaseDiestrus prolongation in PFOS mice
Study
mousen: not reported in source
Female mice exposed to PFOS
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The administration of GPR54 agonist kisspeptin-10 in PFOS-mice could correct the prolongation of diestrus and reduction of corpora luteum, and recover the LH-surge and the levels of LH and GnRH.
Report a problemFND-2993933701
02AnimalAnimal study (in vivo)Efficacy outcome
In female mice exposed to PFOS, kisspeptin‑10 corrected the reduction of corpora luteum.
In plain wordsIn mice exposed to a pollutant, kisspeptin‑10 restored the lower number of corpora luteum.
Peptide
Kisspeptin-10
Outcome
IncreaseCorpora luteum number in PFOS mice
Study
mousen: not reported in source
Female mice exposed to PFOS
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The administration of GPR54 agonist kisspeptin-10 in PFOS-mice could correct the prolongation of diestrus and reduction of corpora luteum, and recover the LH-surge and the levels of LH and GnRH.
Report a problemFND-2993933702
03AnimalAnimal study (in vivo)Efficacy outcome
In female mice exposed to PFOS, kisspeptin‑10 recovered the LH surge.
In plain wordsIn mice exposed to a pollutant, kisspeptin‑10 restored the LH surge.
Peptide
Kisspeptin-10
Outcome
IncreaseLH surge in PFOS mice
Study
mousen: not reported in source
Female mice exposed to PFOS
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The administration of GPR54 agonist kisspeptin-10 in PFOS-mice could correct the prolongation of diestrus and reduction of corpora luteum, and recover the LH-surge and the levels of LH and GnRH.
Report a problemFND-2993933703
04AnimalAnimal study (in vivo)Efficacy outcome
In female mice exposed to PFOS, kisspeptin‑10 recovered the level of LH.
In plain wordsIn mice exposed to a pollutant, kisspeptin‑10 restored LH levels.
Peptide
Kisspeptin-10
Outcome
IncreaseLH level in PFOS mice
Study
mousen: not reported in source
Female mice exposed to PFOS
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The administration of GPR54 agonist kisspeptin-10 in PFOS-mice could correct the prolongation of diestrus and reduction of corpora luteum, and recover the LH-surge and the levels of LH and GnRH.
Report a problemFND-2993933704
05AnimalAnimal study (in vivo)Efficacy outcome
In female mice exposed to PFOS, kisspeptin‑10 recovered the level of GnRH.
In plain wordsIn mice exposed to a pollutant, kisspeptin‑10 restored GnRH levels.
Peptide
Kisspeptin-10
Outcome
IncreaseGnRH level in PFOS mice
Study
mousen: not reported in source
Female mice exposed to PFOS
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
The administration of GPR54 agonist kisspeptin-10 in PFOS-mice could correct the prolongation of diestrus and reduction of corpora luteum, and recover the LH-surge and the levels of LH and GnRH.
Report a problemFND-2993933705

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06AnimalEndogenous levelAnimal study (in vivo)Mechanism
In female mice, PFOS suppressed the increase in the number of AVPV-kisspeptin neurons and in AVPV-kisspeptin expression seen in proestrus or after high-dose estradiol.
In plain wordsIn mice, a pollutant blocked the rise in the body's own kisspeptin cells and kisspeptin levels in one brain region.
Peptide
Kisspeptin-10
Outcome
DecreaseAVPV-kisspeptin neuron number and expression
Study
mousen: not reported in source
Proestrus mice and ovariectomized mice given high-dose estradiol benzoate
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
The number of AVPV-kisspeptin neurons and the AVPV-kisspeptin expression were increased in proestrus mice or OVX-mice treated with high-dose estradiol benzoate (0.05 mg/kg), which were suppressed by the administration of PFOS.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2993933706
07LabEndogenous levelEx vivo tissueMechanism
In mouse hypothalamic slices, 100 nM estradiol for 4 hours significantly increased AVPV-kisspeptin expression.
In plain wordsIn lab tests on mouse brain slices, estradiol raised the body's own kisspeptin levels in one brain region.
Peptide
Kisspeptin-10
Outcome
IncreaseAVPV-kisspeptin expression with estradiol
Study
mousen: not reported in source
Hypothalamic slices incubated in estradiol
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
In hypothalamic slices incubated in 100 nM E2 for 4 h, the AVPV-kisspeptin expression was significantly enhanced
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2993933708
08LabEndogenous levelEx vivo tissueMechanism
In mouse hypothalamic slices, the estradiol-induced rise in AVPV-kisspeptin expression was inhibited by PFOS in a dose-dependent manner or by the ERα antagonist MPP, but not by the ERβ antagonist PHTPP.
In plain wordsIn lab tests on mouse brain slices, a pollutant blocked the estradiol rise in the body's own kisspeptin levels.
Peptide
Kisspeptin-10
Outcome
DecreaseAVPV-kisspeptin expression with PFOS or ER antagonists
Study
mousen: not reported in source
Hypothalamic slices incubated in estradiol
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
which was inhibited by PFOS in a dose-dependent manner or estrogen receptor α (ERα) antagonist MPP, but not ERβ antagonist PHTPP.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2993933709
09LabEndogenous levelEx vivo tissueMechanism
In mouse hypothalamic slices, the ERα agonist PPT, but not the ERβ agonist DPN, increased AVPV-kisspeptin expression, and this was sensitive to PFOS.
In plain wordsIn lab tests on mouse brain slices, an estrogen receptor activator raised the body's own kisspeptin levels, and a pollutant blocked this.
Peptide
Kisspeptin-10
Outcome
IncreaseAVPV-kisspeptin expression with ERα agonist PPT
Study
mousen: not reported in source
Hypothalamic slices
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
The incubation of ERα agonist PPT rather than ERβ agonist DPN could increase the level of AVPV-kisspeptin expression, which was sensitive to the treatment with PFOS.
This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2993933710

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

10AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In ovariectomized mice given high-dose estradiol, PFOS or the GPR54 antagonist P234 prevented the LH surge.
In plain wordsIn mice, a pollutant or a kisspeptin receptor blocker prevented the LH surge.
Peptide
Kisspeptin-10
Outcome
DecreaseLH surge with PFOS or GPR54 antagonist P234
Study
mousen: not reported in source
Ovariectomized mice given high-dose estradiol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The administration of PFOS or GPR54 antagonist P234 prevented the generation of LH-surge in OVX-mice treated with high-dose E2.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2993933707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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