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Study · In vitro (cells) · 2018

6 results

Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.

Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R

Molecular therapy : the journal of the American Society of Gene Therapy19 Jun 2018Cited by 12 (Europe PMC)

PMID29929787 (opens in a new tab)PMCIDPMC6037200 (opens in a new tab)DOI10.1016/j.ymthe.2018.06.004 (opens in a new tab)PepBankPUB-29929787
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In endothelial cells under oxLDL stress, Tβ4 reduced the scratch area compared with oxLDL alone.

    In plain wordsIn lab-grown blood vessel cells under cholesterol stress, thymosin beta‑4 left a smaller scratch gap than cholesterol stress alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseEndothelial scratch area under oxLDL stress
    Study

    n: not reported in source

    Endothelial cells under oxidized LDL stress
    Comparator
    oxLDL alone
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    scratch area
    191.924 pixels
    oxLDL
    scratch area
    105.621 pixels
    oxLDL + Tβ4

    Source sentences

    Summary
    Initial in vitro results highlighted an improved endothelial cell function upon Tβ4 treatment under control conditions and during hypercholesterolemic stress (scratch area [pixels]: oxidized low-density lipoprotein [oxLDL], 191,924 ± 7,717; and oxLDL + Tβ4, 105,621 ± 11,245)

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In pigs with chronic myocardial ischemia on normal or high-fat diet, Tβ4 overexpression improved capillarization.

    In plain wordsIn pigs with poor heart blood flow, a virus that raises Tβ4 gene activity improved the density of tiny blood vessels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCapillarization
    Study

    pign: not reported in source

    Chronic myocardial ischemia on normal or high-fat diet
    Comparator
    rAAV.LacZ control
    Outcome group
    Angiogenesis · Cardiovascular

    Source sentences

    Summary
    Tβ4 overexpression improves capillarization and collateralization
    1 context sentence
    Summary · context
    To mimic the common risk factor of hypercholesterolemia in vivo, pigs on regular (NC) or high-fat (HC) diet underwent chronic myocardial ischemia followed by recombinant adeno-associated virus (rAAV)-mediated transduction of Tβ4 or LacZ as a control.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In pigs on a normal diet with chronic myocardial ischemia, Tβ4 overexpression increased collaterals versus the LacZ control.

    In plain wordsIn pigs on a normal diet with poor heart blood flow, a virus that raises Tβ4 gene activity increased bypass vessels versus a control virus.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCollaterals, normal diet
    Study

    pign: not reported in source

    Chronic myocardial ischemia, normal diet
    Comparator
    rAAV.LacZ control
    Outcome group
    Angiogenesis · Cardiovascular

    Measurements

    collaterals
    2.1 count
    NC + rAAV.LacZ
    collaterals
    6.7 count
    NC + rAAV.Tβ4

    Source sentences

    Summary
    collaterals: NC + rAAV.LacZ, 2.1 ± 0.5; NC + rAAV.Tβ4, 6.7 ± 0.5
    1 context sentence
    Summary · context
    To mimic the common risk factor of hypercholesterolemia in vivo, pigs on regular (NC) or high-fat (HC) diet underwent chronic myocardial ischemia followed by recombinant adeno-associated virus (rAAV)-mediated transduction of Tβ4 or LacZ as a control.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In pigs on a high-fat diet with chronic myocardial ischemia, Tβ4 overexpression increased collaterals versus the LacZ control.

    In plain wordsIn pigs on a high-fat diet with poor heart blood flow, a virus that raises Tβ4 gene activity increased bypass vessels versus a control virus.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCollaterals, high-fat diet
    Study

    pign: not reported in source

    Chronic myocardial ischemia, high-fat diet
    Comparator
    rAAV.LacZ control
    Outcome group
    Angiogenesis · Cardiovascular

    Measurements

    collaterals
    3 count
    HC + rAAV.LacZ
    collaterals
    6 count
    HC + rAAV.Tβ4

    Source sentences

    Summary
    HC + rAAV.LacZ, 3.0 ± 0.3; and HC + rAAV.Tβ4, 6.0 ± 0.4
    1 context sentence
    Summary · context
    To mimic the common risk factor of hypercholesterolemia in vivo, pigs on regular (NC) or high-fat (HC) diet underwent chronic myocardial ischemia followed by recombinant adeno-associated virus (rAAV)-mediated transduction of Tβ4 or LacZ as a control.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In pigs on a normal diet with chronic myocardial ischemia, Tβ4 overexpression raised ejection fraction at day 56 versus the LacZ control.

    In plain wordsIn pigs on a normal diet with poor heart blood flow, a virus that raises Tβ4 gene activity raised ejection fraction at day 56.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEjection fraction at day 56, normal diet
    Study

    pign: not reported in source

    Chronic myocardial ischemia, normal diet
    Comparator
    rAAV.LacZ control
    Outcome group
    Heart function · Cardiovascular

    Measurements

    ejection fraction at day 56
    26%
    NC + rAAV.LacZ
    ejection fraction at day 56
    45%
    NC + rAAV.Tβ4

    Source sentences

    Summary
    ejection fraction [EF] at day 56 [%]: NC + rAAV.LacZ, 26 ± 1.1; NC + rAAV.Tβ4, 45 ± 1.5
    1 context sentence
    Summary · context
    To mimic the common risk factor of hypercholesterolemia in vivo, pigs on regular (NC) or high-fat (HC) diet underwent chronic myocardial ischemia followed by recombinant adeno-associated virus (rAAV)-mediated transduction of Tβ4 or LacZ as a control.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 06AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In pigs on a high-fat diet with chronic myocardial ischemia, Tβ4 overexpression raised ejection fraction at day 56 versus the LacZ control.

    In plain wordsIn pigs on a high-fat diet with poor heart blood flow, a virus that raises Tβ4 gene activity raised ejection fraction at day 56.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEjection fraction at day 56, high-fat diet
    Study

    pign: not reported in source

    Chronic myocardial ischemia, high-fat diet
    Comparator
    rAAV.LacZ control
    Outcome group
    Heart function · Cardiovascular

    Measurements

    ejection fraction at day 56
    26%
    HC + rAAV.LacZ
    ejection fraction at day 56
    41%
    HC + rAAV.Tβ4

    Source sentences

    Summary
    HC + rAAV.LacZ, 26 ± 2.5; and HC + rAAV.Tβ4, 41 ± 2.6
    1 context sentence
    Summary · context
    To mimic the common risk factor of hypercholesterolemia in vivo, pigs on regular (NC) or high-fat (HC) diet underwent chronic myocardial ischemia followed by recombinant adeno-associated virus (rAAV)-mediated transduction of Tβ4 or LacZ as a control.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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