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Study · Animal study (in vivo) · rat · 2018

4 results

Thymosin beta 4 induces significant changes in the plasma miRNA profile following severe traumatic brain injury in the rat lateral fluid percussion injury model.

Osei J, Kelly W, Toffolo K, Donahue K, Levy B, Bard J, Wang J, Levy E, Nowak N, Poulsen D

Expert opinion on biological therapy1 Jul 2018Cited by 15 (Europe PMC)

PMID29873258 (opens in a new tab)DOI10.1080/14712598.2018.1484102 (opens in a new tab)PepBankPUB-29873258
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with severe traumatic brain injury, Tβ4 treatment increased plasma miR-200a-3p.

    In plain wordsIn rats with severe brain injury, thymosin beta‑4 treatment raised the level of one microRNA in blood.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePlasma miR-200a-3p after severe TBI
    Study

    ratn: not reported in source

    Lateral fluid percussion injury model of severe traumatic brain injury
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ddPCR demonstrated that miR-200a-3p andmiR-200b-3p were both significantly increased in plasma following treatment with Tβ4 after severe TBI.
    1 context sentence
    Summary · context
    We used the rat lateral fluid percusion injury model of severe TBI to test this hypothesis.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with severe traumatic brain injury, Tβ4 treatment increased plasma miR-200b-3p.

    In plain wordsIn rats with severe brain injury, thymosin beta‑4 treatment raised the level of another microRNA in blood.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePlasma miR-200b-3p after severe TBI
    Study

    ratn: not reported in source

    Lateral fluid percussion injury model of severe traumatic brain injury
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ddPCR demonstrated that miR-200a-3p andmiR-200b-3p were both significantly increased in plasma following treatment with Tβ4 after severe TBI.
    1 context sentence
    Summary · context
    We used the rat lateral fluid percusion injury model of severe TBI to test this hypothesis.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with severe traumatic brain injury, plasma miR-194-5p was significantly higher in Tβ4-treated rats.

    In plain wordsIn rats with severe brain injury, thymosin beta‑4 treatment was linked to a higher level of one microRNA in blood.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePlasma miR-194-5p in Tβ4-treated rats after TBI
    Study

    ratn: not reported in source

    Lateral fluid percussion injury model of severe traumatic brain injury
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, miR-194-5p significantly increased in Tβ4 treated rats following TBI.
    1 context sentence
    Summary · context
    We used the rat lateral fluid percusion injury model of severe TBI to test this hypothesis.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with severe traumatic brain injury, nine plasma miRNAs changed significantly after Tβ4 treatment.

    In plain wordsIn rats with severe brain injury, thymosin beta‑4 treatment changed the levels of nine microRNAs in blood.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedPlasma miRNAs changed by Tβ4 treatment
    Study

    ratn: not reported in source

    Lateral fluid percussion injury model of severe traumatic brain injury
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we identified nine plasma miRNAs whose expression significantly changed following treatment with Tβ4.
    1 context sentence
    Summary · context
    In addition, we conducted RNAseq analysis of plasma miRNA to further identify changes associated with TBI and treatment with Tβ4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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