Skip to content

Study · Animal study (in vivo) · rat · 2018

6 results

Ameliorating effect of kisspeptin-10 on methotrexate-induced sperm damages and testicular oxidative stress in rats.

Güvenç M, Aksakal M

Andrologia3 Jun 2018Cited by 20 (Europe PMC)

PMID29862548 (opens in a new tab)DOI10.1111/and.13057 (opens in a new tab)PepBankPUB-29862548
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given methotrexate, kisspeptin‑10 treatment significantly reduced the malondialdehyde level that methotrexate had raised.

    In plain wordsIn rats given methotrexate, kisspeptin‑10 lowered a marker of oxidative damage compared with methotrexate alone.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseTesticular malondialdehyde
    Study

    ratn = 20

    Methotrexate-induced reproductive toxicity
    Comparator
    Methotrexate alone
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    At the end of the study, malondialdehyde levels were found to have increased following the application of MTX while showing a significant reduction in group 4 with Kiss administration.
    1 context sentence
    Summary · context
    Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given methotrexate, kisspeptin‑10 treatment increased sperm motility compared with methotrexate alone.

    In plain wordsIn rats given methotrexate, kisspeptin‑10 improved sperm movement compared with methotrexate alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSperm motility
    Study

    ratn = 20

    Methotrexate-induced reproductive toxicity
    Comparator
    Methotrexate alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    while improvements were observed in group 4 in the form of increased motility in the spermatozoa and fewer abnormal spermatozoa.
    1 context sentence
    Summary · context
    Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats given methotrexate, kisspeptin‑10 treatment reduced the rate of abnormal spermatozoa compared with methotrexate alone.

    In plain wordsIn rats given methotrexate, kisspeptin‑10 gave fewer abnormal sperm than methotrexate alone.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseAbnormal spermatozoa rate
    Study

    ratn = 20

    Methotrexate-induced reproductive toxicity
    Comparator
    Methotrexate alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    while improvements were observed in group 4 in the form of increased motility in the spermatozoa and fewer abnormal spermatozoa.
    1 context sentence
    Summary · context
    Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats given methotrexate, kisspeptin‑10 significantly increased the absolute weight of the seminal vesicles compared with methotrexate alone.

    In plain wordsIn rats given methotrexate, kisspeptin‑10 raised seminal vesicle weight compared with methotrexate alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseAbsolute seminal vesicle weight
    Study

    ratn = 20

    Methotrexate-induced reproductive toxicity
    Comparator
    Methotrexate alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    In addition, Kiss treatment provided statistically significant increases in the absolute weight of the seminal vesicles and the relative weights of the right cauda epididymis and seminal vesicles resulting from MTX administration.
    1 context sentence
    Summary · context
    Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats given methotrexate, kisspeptin‑10 significantly increased the relative weight of the right cauda epididymis compared with methotrexate alone.

    In plain wordsIn rats given methotrexate, kisspeptin‑10 raised the relative weight of a sperm-storage organ compared with methotrexate alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseRelative right cauda epididymis weight
    Study

    ratn = 20

    Methotrexate-induced reproductive toxicity
    Comparator
    Methotrexate alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    In addition, Kiss treatment provided statistically significant increases in the absolute weight of the seminal vesicles and the relative weights of the right cauda epididymis and seminal vesicles resulting from MTX administration.
    1 context sentence
    Summary · context
    Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats given methotrexate, kisspeptin‑10 significantly increased the relative weight of the seminal vesicles compared with methotrexate alone.

    In plain wordsIn rats given methotrexate, kisspeptin‑10 raised relative seminal vesicle weight compared with methotrexate alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseRelative seminal vesicle weight
    Study

    ratn = 20

    Methotrexate-induced reproductive toxicity
    Comparator
    Methotrexate alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 nmol/kg · intraperitoneal · 10 daysAs given in this study (rat).

    Source sentences

    Summary
    In addition, Kiss treatment provided statistically significant increases in the absolute weight of the seminal vesicles and the relative weights of the right cauda epididymis and seminal vesicles resulting from MTX administration.
    1 context sentence
    Summary · context
    Group 1 (n:6) received saline only; group 2 (n:6) received 50 nmol/kg kisspeptin-10 for 10 days; group 3 (n:10) received single-dose methotrexate 20 mg/kg; and group 4 (n:10) received MTX 20 mg/kg single dose and, after 3 days, received kisspeptin-10, 50 nmol/kg, lasted for 10 days by intraperitoneal injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.