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Study · Animal study (in vivo) · rat · 2018

6 results

Effect of Thymalin on the Tumor and Thymus under Conditions of Activation Therapy In Vivo.

Zhukova GV, Schikhlyarova AI, Barteneva TA, Shevchenko AN, Zakharyuta FM

Bulletin of experimental biology and medicine24 May 2018Cited by 4 (Europe PMC)

PMID29797130 (opens in a new tab)DOI10.1007/s10517-018-4104-z (opens in a new tab)PepBankPUB-29797130
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with transplanted sarcoma 45, Thymalin produced tumor growth arrest and regression in more than half of animals.

    In plain wordsIn rats with transplanted tumors, Thymalin stopped tumor growth and produced regression in more than half of animals.

    Peptide
    Thymalin
    Outcome
    DecreaseTumor growth arrest and regression
    Study

    ratn: not reported in source

    Albino outbred male rats with transplanted sarcoma 45
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Doses lower than the therapeutic dosesAs given in this study (rat).

    Source sentences

    Summary
    Tumor growth arrest and its regression were observed in more than half of animals and in other cases, the growth was suppressed by 78%.
    1 context sentence
    Summary · context
    Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In other rats with transplanted sarcoma 45, Thymalin suppressed tumor growth by 78%.

    In plain wordsIn rats without the reported tumor arrest and regression, Thymalin suppressed tumor growth by 78%.

    Peptide
    Thymalin
    Outcome
    DecreaseTumor growth suppression in other animals
    Study

    ratn: not reported in source

    Albino outbred male rats with transplanted sarcoma 45
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Doses lower than the therapeutic dosesAs given in this study (rat).

    Measurements

    Tumor growth suppression
    78%
    Other animals

    Source sentences

    Summary
    Tumor growth arrest and its regression were observed in more than half of animals and in other cases, the growth was suppressed by 78%.
    1 context sentence
    Summary · context
    Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with transplanted sarcoma 45, Thymalin significantly increased thymic lymphoproliferative activity.

    In plain wordsIn rats with transplanted tumors, Thymalin increased lymphocyte proliferation in the thymus.

    Peptide
    Thymalin
    Outcome
    IncreaseThymic lymphoproliferative activity
    Study

    ratn: not reported in source

    Albino outbred male rats with transplanted sarcoma 45
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Doses lower than the therapeutic dosesAs given in this study (rat).

    Source sentences

    Summary
    Significant increase in lymphoproliferative activity and the content of tissue basophils and plasmocytes in the thymus lobules was observed.
    1 context sentence
    Summary · context
    Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with transplanted sarcoma 45, Thymalin significantly increased tissue basophil content in thymus lobules.

    In plain wordsIn rats with transplanted tumors, Thymalin increased basophil content in the thymus.

    Peptide
    Thymalin
    Outcome
    IncreaseThymic tissue basophil content
    Study

    ratn: not reported in source

    Albino outbred male rats with transplanted sarcoma 45
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Doses lower than the therapeutic dosesAs given in this study (rat).

    Source sentences

    Summary
    Significant increase in lymphoproliferative activity and the content of tissue basophils and plasmocytes in the thymus lobules was observed.
    1 context sentence
    Summary · context
    Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with transplanted sarcoma 45, Thymalin significantly increased plasmocyte content in thymus lobules.

    In plain wordsIn rats with transplanted tumors, Thymalin increased plasma cell content in the thymus.

    Peptide
    Thymalin
    Outcome
    IncreaseThymic plasmocyte content
    Study

    ratn: not reported in source

    Albino outbred male rats with transplanted sarcoma 45
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Doses lower than the therapeutic dosesAs given in this study (rat).

    Source sentences

    Summary
    Significant increase in lymphoproliferative activity and the content of tissue basophils and plasmocytes in the thymus lobules was observed.
    1 context sentence
    Summary · context
    Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats treated with Thymalin, tumor regression accompanied stable antistress adaptation reactions of calm and elevated activation.

    In plain wordsIn rats treated with Thymalin, tumor regression accompanied stable antistress adaptation responses.

    Peptide
    Thymalin
    Outcome
    Not applicableAntistress adaptation reactions
    Study

    ratn: not reported in source

    Albino outbred male rats with transplanted sarcoma 45
    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Doses lower than the therapeutic dosesAs given in this study (rat).

    Source sentences

    Summary
    Tumor regression was accompanied by the development of stable antistress adaptation reactions of calm and elevated activation.
    1 context sentence
    Summary · context
    Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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