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Study · Animal study (in vivo) · mouse · 2018

5 results

Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons.

Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP

Diabetes18 May 2018Cited by 138 (Europe PMC)

PMID29776968 (opens in a new tab)PMCIDPMC6054439 (opens in a new tab)DOI10.2337/db17-1385 (opens in a new tab)PepBankPUB-29776968
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice lacking GLP-1 receptors in vGAT-expressing GABAergic neurons, liraglutide responses were identical to controls in all parameters measured.

    In plain wordsIn mice, removing GLP-1 receptors from GABAergic neurons did not change responses to liraglutide.

    Peptide
    Liraglutide
    Outcome
    Not applicableLiraglutide effects in mice lacking GLP-1R in GABAergic (vGAT) neurons
    Study

    mousen: not reported in source

    Mice with GLP-1R deletion in vGAT or vGlut2 neurons
    Comparator
    Control mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    mice lacking GLP-1Rs in vGAT-expressing GABAergic neurons responded identically to controls in all parameters measured
    1 context sentence
    Summary · context
    We determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the short- and long-term effects of the GLP1RA liraglutide on food intake, visceral illness, body weight, and neural network activation.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, deletion of GLP-1 receptors in vGlut2-expressing glutamatergic neurons eliminated liraglutide-induced weight loss.

    In plain wordsIn mice, removing GLP-1 receptors from glutamatergic neurons stopped liraglutide from causing weight loss.

    Peptide
    Liraglutide
    Outcome
    Not applicableLiraglutide-induced weight loss in mice lacking GLP-1R in glutamatergic (vGlut2) neurons
    Study

    mousen: not reported in source

    Mice with GLP-1R deletion in vGAT or vGlut2 neurons
    Comparator
    Control mice
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    deletion of GLP-1Rs in vGlut2-expressing glutamatergic neurons eliminated liraglutide-induced weight loss
    1 context sentence
    Summary · context
    We determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the short- and long-term effects of the GLP1RA liraglutide on food intake, visceral illness, body weight, and neural network activation.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, deletion of GLP-1 receptors in vGlut2-expressing glutamatergic neurons eliminated liraglutide-induced visceral illness.

    In plain wordsIn mice, removing GLP-1 receptors from glutamatergic neurons stopped liraglutide from causing visceral illness.

    Peptide
    Liraglutide
    Outcome
    Not applicableLiraglutide-induced visceral illness in mice lacking GLP-1R in glutamatergic (vGlut2) neurons
    Study

    mousen: not reported in source

    Mice with GLP-1R deletion in vGAT or vGlut2 neurons
    Comparator
    Control mice
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    deletion of GLP-1Rs in vGlut2-expressing glutamatergic neurons eliminated liraglutide-induced weight loss and visceral illness
    1 context sentence
    Summary · context
    We determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the short- and long-term effects of the GLP1RA liraglutide on food intake, visceral illness, body weight, and neural network activation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, deletion of GLP-1 receptors in vGlut2-expressing glutamatergic neurons severely attenuated the effects of liraglutide on feeding.

    In plain wordsIn mice, removing GLP-1 receptors from glutamatergic neurons strongly reduced the effect of liraglutide on feeding.

    Peptide
    Liraglutide
    Outcome
    Not applicableLiraglutide effect on feeding in mice lacking GLP-1R in glutamatergic (vGlut2) neurons
    Study

    mousen: not reported in source

    Mice with GLP-1R deletion in vGAT or vGlut2 neurons
    Comparator
    Control mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    deletion of GLP-1Rs in vGlut2-expressing glutamatergic neurons eliminated liraglutide-induced weight loss and visceral illness and severely attenuated its effects on feeding.
    1 context sentence
    Summary · context
    We determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the short- and long-term effects of the GLP1RA liraglutide on food intake, visceral illness, body weight, and neural network activation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, deletion of GLP-1 receptors from glutamatergic neurons completely abolished the neural network activation seen after liraglutide administration.

    In plain wordsIn mice, removing GLP-1 receptors from glutamatergic neurons completely stopped the brain network activation seen after liraglutide.

    Peptide
    Liraglutide
    Outcome
    Not applicableLiraglutide-induced neural network activation in mice lacking GLP-1R in glutamatergic neurons
    Study

    mousen: not reported in source

    Mice with GLP-1R deletion in vGAT or vGlut2 neurons
    Comparator
    Control mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Concomitantly, deletion of GLP-1Rs from glutamatergic neurons completely abolished the neural network activation observed after liraglutide administration.
    1 context sentence
    Summary · context
    We determined whether GLP-1Rs in either GABAergic or glutamatergic neurons are necessary for the short- and long-term effects of the GLP1RA liraglutide on food intake, visceral illness, body weight, and neural network activation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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