Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.

Lue Y, Gao C, Swerdloff R, Hoang J, Avetisyan R, Jia Y, Rao M, Ren S, Atienza V, Yu J, Zhang Y, Chen M, Song Y, Wang Y, Wang C

American journal of physiology. Heart and circulatory physiology18 May 2018Cited by 29 (Europe PMC)

PMID29775411PMCIDPMC6734085DOI10.1152/ajpheart.00155.2018PepBankPUB-29775411

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In mice not given Dox, HNG had no adverse effect on the heart.
In plain wordsIn mice without doxorubicin, a humanin analogue had no harmful effect on the heart.
Peptide
Humanin
Outcome
No significant changeHeart effects of HNG without Dox
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
5 mg/kg daily · intraperitoneal · 10 weeksAs given in this study (mouse).
Source sentences
Summary
In the absence of Dox, HNG, DRZ, or DRZ + HNG had no adverse effect on the heart.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
Report a problemFND-2977541101
02AnimalAnimal study (in vivo)Efficacy outcome
In Dox-treated mice, HNG alone blunted the Dox-induced decrease in left ventricle posterior wall thickness.
In plain wordsIn mice given doxorubicin, a humanin analogue reduced the drop in heart wall thickness.
Peptide
Humanin
Outcome
IncreaseDox-induced decrease in left ventricle posterior wall thickness
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Comparator
Dox alone
Outcome group
Heart function · Cardiovascular
Studied dose
5 mg/kg daily · intraperitoneal · 10 weeksAs given in this study (mouse).
Source sentences
Summary
HNG or DRZ alone blunted the Dox-induced decrease in left ventricle posterior wall thickness and modestly ameliorated the Dox-induced decrease in ejection fraction.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
Report a problemFND-2977541102
03AnimalAnimal study (in vivo)Efficacy outcome
In Dox-treated mice, HNG alone modestly ameliorated the Dox-induced decrease in ejection fraction.
In plain wordsIn mice given doxorubicin, a humanin analogue modestly reduced the drop in heart pumping function.
Peptide
Humanin
Outcome
IncreaseDox-induced decrease in ejection fraction
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Comparator
Dox alone
Outcome group
Heart function · Cardiovascular
Studied dose
5 mg/kg daily · intraperitoneal · 10 weeksAs given in this study (mouse).
Source sentences
Summary
HNG or DRZ alone blunted the Dox-induced decrease in left ventricle posterior wall thickness and modestly ameliorated the Dox-induced decrease in ejection fraction.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
Report a problemFND-2977541103
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, adding HNG to dexrazoxane enhanced the cardiac protective effect of dexrazoxane against Dox-induced cardiac dysfunction.
In plain wordsIn mice given doxorubicin, adding a humanin analogue to dexrazoxane protected the heart more than dexrazoxane alone.
Peptide
Humanin
Outcome
IncreaseHNG added to DRZ against Dox-induced cardiac dysfunction
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Comparator
Dexrazoxane
Outcome group
Heart function · Cardiovascular
Studied dose
5 mg/kg daily · intraperitoneal · 10 weeksAs given in this study (mouse).
Source sentences
Summary
We demonstrated in this study that treating young adult male mice with synthetic humanin analog enhanced the cardiac protective effect of dexrazoxane against chemotherapeutic agent Dox-induced cardiac dysfunction.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
Report a problemFND-2977541108

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

05AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In Dox-treated mice, the combination of HNG and dexrazoxane significantly ameliorated the Dox-induced decrease in ejection function.
In plain wordsIn mice given doxorubicin, a humanin analogue plus dexrazoxane reduced the drop in heart pumping function.
Peptide
Humanin
Outcome
IncreaseEjection function with HNG + DRZ
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
HNG + DRZ significantly ameliorated Dox-induced decreases in ejection function, cardiac fibrosis, and cardiac mass.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2977541104
06AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In Dox-treated mice, the combination of HNG and dexrazoxane significantly ameliorated Dox-induced cardiac fibrosis.
In plain wordsIn mice given doxorubicin, a humanin analogue plus dexrazoxane reduced heart scarring.
Peptide
Humanin
Outcome
DecreaseCardiac fibrosis with HNG + DRZ
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
HNG + DRZ significantly ameliorated Dox-induced decreases in ejection function, cardiac fibrosis, and cardiac mass.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2977541105
07AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In Dox-treated mice, the combination of HNG and dexrazoxane significantly ameliorated the Dox-induced decrease in cardiac mass.
In plain wordsIn mice given doxorubicin, a humanin analogue plus dexrazoxane reduced the loss of heart mass.
Peptide
Humanin
Outcome
IncreaseCardiac mass with HNG + DRZ
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
HNG + DRZ significantly ameliorated Dox-induced decreases in ejection function, cardiac fibrosis, and cardiac mass.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2977541106
08AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In Dox-treated mice, the combination of HNG and dexrazoxane reversed Dox-induced altered transcripts that were biomarkers of cardiac damage and uncoupling protein-2.
In plain wordsIn mice given doxorubicin, a humanin analogue plus dexrazoxane reversed doxorubicin-induced changes in heart damage markers.
Peptide
Humanin
Outcome
MixedDox-induced altered transcripts and UCP2 with HNG + DRZ
Study
mousen: not reported in source
Doxorubicin-induced cardiotoxicity in adult male mice
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Using a targeted analysis for the mitochondrial gene array and protein expression in heart tissues, we demonstrated that HNG + DRZ reversed DOX-induced altered transcripts that were biomarkers of cardiac damage and uncoupling protein-2.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the cardioprotective efficacy of HNG alone or in combination with DRZ against Dox-induced cardiotoxicity, 80 adult male mice were randomly divided into 8 groups to receive the following treatments via intraperitoneal injection: saline dailym HNG (5 mg/kg) daily, DRZ (60 mg/kg) weekly,…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2977541107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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