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Study · Not a test of the peptide alone · 2018

2 results

Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss.

Hou S, Yang Y, Zhou S, Kuang X, Yang Y, Gao H, Wang Z, Liu H

Biomaterials science1 May 2018Cited by 20 (Europe PMC)

PMID29740652 (opens in a new tab)DOI10.1039/c7bm01181d (opens in a new tab)PepBankPUB-29740652
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

  1. 01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome

    In zebrafish, SS‑31 modified, minocycline-loaded liposomes increased hair cell survival against chronic gentamicin exposure.

    In plain wordsIn zebrafish, liposomes carrying minocycline and modified with SS‑31 protected hair cells from gentamicin.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseHair cell survival against chronic gentamicin
    Study

    zebrafishn: not reported in source

    Zebrafish gentamicin hair cell model
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The results revealed that SS-31 modified, minocycline-loaded liposomes significantly increased hair cell survival against chronic exposure to gentamicin in a zebrafish model.
    1 context sentence
    Summary · context
    Inspired by our previous research, we used a mitochondria-targeting tetrapeptide, SS-31, to modify the surface of liposomes.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

  2. 02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism

    In zebrafish hair cells, the SS‑31 modified liposome formulation maintained mechanotransduction channel activity and did not alter gentamicin uptake.

    In plain wordsIn zebrafish, the SS‑31 liposomes kept hair cell channels working and did not change how much gentamicin entered the cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeMechanotransduction channel activity and gentamicin uptake
    Study

    zebrafishn: not reported in source

    Zebrafish gentamicin hair cell model
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The designed formulation maintained the activity of mechanotransduction channels in the hair cells, and thus did not result in any alteration in gentamicin uptake.
    1 context sentence
    Summary · context
    Inspired by our previous research, we used a mitochondria-targeting tetrapeptide, SS-31, to modify the surface of liposomes.

    In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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