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Study · Animal study (in vivo) · pig · 2018

9 results

Mitoprotection preserves the renal vasculature in porcine metabolic syndrome.

Eirin A, Hedayat AF, Ferguson CM, Textor SC, Lerman A, Lerman LO

Experimental physiology27 May 2018Cited by 21 (Europe PMC)

PMID29714040 (opens in a new tab)PMCIDPMC6026037 (opens in a new tab)DOI10.1113/ep086988 (opens in a new tab)PepBankPUB-29714040
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved mitochondrial density in renal peritubular capillary endothelial cells.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved the number of mitochondria in kidney capillary lining cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreasePTC endothelial cell mitochondrial density
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitochondrial density and cardiolipin content were diminished in MetS PTC-ECs, but improved in ELAM-treated pigs, as did PTC density.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved cardiolipin content in renal peritubular capillary endothelial cells.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved a key mitochondrial membrane fat in kidney capillary cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreasePTC endothelial cell cardiolipin content
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitochondrial density and cardiolipin content were diminished in MetS PTC-ECs, but improved in ELAM-treated pigs, as did PTC density.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved peritubular capillary density.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved the density of small kidney blood vessels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreasePeritubular capillary density
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Mitochondrial density and cardiolipin content were diminished in MetS PTC-ECs, but improved in ELAM-treated pigs, as did PTC density.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide attenuated oxidative stress in renal peritubular capillary endothelial cells.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reduced oxidative stress in kidney capillary cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePTC endothelial cell oxidative stress
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Oxidative stress · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Elamipretide also attenuated PTC-EC oxidative stress and apoptosis.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide attenuated apoptosis in renal peritubular capillary endothelial cells.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reduced cell death in kidney capillary cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreasePTC endothelial cell apoptosis
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Cell viability and death · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Elamipretide also attenuated PTC-EC oxidative stress and apoptosis.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved renal microvascular density.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved the density of small blood vessels in the kidney.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseRenal microvascular density
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Furthermore, ELAM improved renal microvascular density, decreased microvascular remodelling and restored endothelial nitric oxide expression and endothelium-dependent relaxation of renal artery segments.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide decreased renal microvascular remodelling.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reduced harmful changes in the structure of kidney blood vessels.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseRenal microvascular remodelling
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Furthermore, ELAM improved renal microvascular density, decreased microvascular remodelling and restored endothelial nitric oxide expression and endothelium-dependent relaxation of renal artery segments.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide restored endothelial nitric oxide expression in the kidney.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored nitric oxide expression in kidney blood vessel lining.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseEndothelial nitric oxide expression
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Furthermore, ELAM improved renal microvascular density, decreased microvascular remodelling and restored endothelial nitric oxide expression and endothelium-dependent relaxation of renal artery segments.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide restored endothelium-dependent relaxation of renal artery segments.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored the ability of kidney artery segments to relax.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseEndothelium-dependent relaxation of renal artery segments
    Study

    pign = 6

    Diet-induced metabolic syndrome in pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    0.1 mg/kg daily · injection · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    Furthermore, ELAM improved renal microvascular density, decreased microvascular remodelling and restored endothelial nitric oxide expression and endothelium-dependent relaxation of renal artery segments.
    1 context sentence
    Summary · context
    Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with daily injections of ELAM (0.1 mg kg-1 ), and lean control (Lean) animals (n = 6 each).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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