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Study · Randomized controlled trial · n = 28 · 2018

3 results

Liraglutide increases IVF pregnancy rates in obese PCOS women with poor response to first-line reproductive treatments: a pilot randomized study.

Salamun V, Jensterle M, Janez A, Vrtacnik Bokal E

European journal of endocrinology27 Apr 2018Cited by 155 (Europe PMC)

PMID29703793 (opens in a new tab)DOI10.1530/eje-18-0175 (opens in a new tab)PepBankPUB-29703793
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In infertile obese women with PCOS, adding liraglutide to metformin gave no significant extra weight loss compared with metformin alone over 12 weeks.

    In plain wordsIn infertile obese women with PCOS, adding liraglutide to metformin did not produce significantly more weight loss than metformin alone.

    Peptide
    Liraglutide
    Outcome
    No significant changeBody weight loss, metformin plus liraglutide versus metformin alone
    Study

    n = 28

    Comparator
    Metformin alone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.2 mg once daily · subcutaneous · 12 weeksAs given in this study (human).

    Measurements

    Weight loss
    7.5 kg
    metformin plus liraglutide
    Weight loss
    7 kg
    metformin alone

    Source sentences

    Summary
    Patients in the MET group on average lost 7.0 ± 6.0 kg (P = 0.001) compared with 7.5 ± 3.9 kg in the COMBI group (P P = 0.246).
    2 context sentences
    Summary · context
    A prospective randomized open-label study was conducted in 28 infertile obese PCOS patients (age: 31.07 ± 4.75, BMI: 36.7 ± 3.5 kg/m2, mean ± s.d.).
    Summary · context
    They were assigned to metformin (MET) 1000 mg BID or to MET 1000 mg BID combined with low-dose liraglutide 1.2 mg QD s.c. (COMBI) for 12 weeks.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In infertile obese women with PCOS, the cumulative pregnancy rate over 12 months was higher after metformin plus liraglutide than after metformin alone.

    In plain wordsIn infertile obese women with PCOS, adding liraglutide to metformin was followed by a higher 12-month cumulative pregnancy rate than metformin alone.

    Peptide
    Liraglutide
    Outcome
    IncreaseCumulative pregnancy rate over 12 months
    Study

    n = 28

    Comparator
    Metformin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1.2 mg once daily · subcutaneous · 12 weeksAs given in this study (human).

    Measurements

    Cumulative pregnancy rate
    69.2%
    metformin plus liraglutide
    Cumulative pregnancy rate
    35.7%
    metformin alone

    Source sentences

    Summary
    The cumulative PR in the time frame of 12 months was 69.2% in the COMBI group compared to 35.7% in the MET group.
    3 context sentences
    Summary · context
    Preconception intervention with low-dose liraglutide added to metformin is superior to metformin alone in increasing PRs per ET and cumulative PRs
    Summary · context
    A prospective randomized open-label study was conducted in 28 infertile obese PCOS patients (age: 31.07 ± 4.75, BMI: 36.7 ± 3.5 kg/m2, mean ± s.d.).
    Summary · context
    They were assigned to metformin (MET) 1000 mg BID or to MET 1000 mg BID combined with low-dose liraglutide 1.2 mg QD s.c. (COMBI) for 12 weeks.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In infertile obese women with PCOS, the IVF pregnancy rate per embryo transfer was significantly higher after metformin plus liraglutide than after metformin alone.

    In plain wordsIn infertile obese women with PCOS, adding liraglutide to metformin was followed by a higher IVF pregnancy rate per embryo transfer than metformin alone.

    Peptide
    Liraglutide
    Outcome
    IncreaseIVF pregnancy rate per embryo transfer
    Study

    n: not reported in source

    Comparator
    Metformin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1.2 mg once daily · subcutaneous · 12 weeksAs given in this study (human).

    Measurements

    Pregnancy rate per ET
    85.7%
    metformin plus liraglutide
    Pregnancy rate per ET
    28.6%
    metformin alone

    Source sentences

    Summary
    The PR per ET was significantly higher in the COMBI (85.7%) compared with the MET (28.6%) group (P = 0.03).
    2 context sentences
    Summary · context
    A prospective randomized open-label study was conducted in 28 infertile obese PCOS patients (age: 31.07 ± 4.75, BMI: 36.7 ± 3.5 kg/m2, mean ± s.d.).
    Summary · context
    They were assigned to metformin (MET) 1000 mg BID or to MET 1000 mg BID combined with low-dose liraglutide 1.2 mg QD s.c. (COMBI) for 12 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials3

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

3 trials · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)

RecruitingPhase 4NCT07242534

Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization.

Fundacion Dexeusn = 6219 Jan 2026 to est. May 2027

Infertility · Obesity

Trial pageClinicalTrials.govUpdated 21 Jan 2026
Status unknownPhase 3NCT05952882

Liraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and Infertility

Mỹ Đức Hospitaln = 188est. 1 Nov 2023 to est. 31 Dec 2025

Polycystic Ovary Syndrome · Obesity · Infertility, Female

Trial pageClinicalTrials.govUpdated 23 Oct 2023
Status unknownPhase 4NCT05702905

Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome

Peking University First Hospitaln = 759 May 2023 to est. 30 Jun 2025

PCOS (Polycystic Ovary Syndrome) · Semaglutide

Trial pageClinicalTrials.govUpdated 25 Mar 2024

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:10 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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