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Study · Animal study (in vivo) · honeybee (apis mellifera) · 2018

3 results

Stable gastric pentadecapeptide BPC 157 in honeybee (Apis mellifera) therapy, to control Nosema ceranae invasions in apiary conditions.

Tlak Gajger I, Ribarić J, Smodiš Škerl M, Vlainić J, Sikirić P

Journal of veterinary pharmacology and therapeutics23 Apr 2018Cited by 32 (Europe PMC)

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In honeybee colonies infected with Nosema ceranae, colony strength was increased 20 and 30 days after initial feeding with BPC‑157-supplemented sugar syrup, compared with Day 1.

    In plain wordsIn honeybee colonies, colonies fed BPC‑157 syrup were larger after 20 and 30 days than at the start.

    Peptide
    BPC-157
    Outcome
    IncreaseStrength of honeybee colonies (estimated number of honeybees)
    Study

    Honeybee (Apis mellifera)n: not reported in source

    Honeybee colonies with Nosema ceranae invasion, apiary field conditions
    Comparator
    Day 1 (start of feeding)
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    0.1 μg/ml BPC 157 in sugar syrup (0.25 L) · Oral, in sugar syrup · 21 consecutive daysAs given in this study (Honeybee (Apis mellifera)).

    Measurements

    Colony strength (estimated number of honeybees)
    36.1 estimated number of honeybees (as written)
    Day 1 (± 698)
    Colony strength (estimated number of honeybees)
    64.86 estimated number of honeybees (as written)
    Day 20 (± 468)
    Colony strength (estimated number of honeybees)
    53.214 estimated number of honeybees (as written)
    Day 30 (± 312)

    Source sentences

    Summary
    The strength of honeybee colonies was increased 20 and 30 days after initial feeding with BPC 157 supplement (Day 1, 36.100 ± 698; Day 20, 64.860 ± 468; Day 30, 53.214 ± 312 estimated number of honeybees), in field conditions.
    1 context sentence
    Summary · context
    BPC 157 treated sugar syrup (0.25 L sugar syrup supplemented with 0.1 μg/ml BPC 157), as well as the pure sugar syrup (0.25 L sugar syrup; control), was administered to honeybee colonies in feeders situated under the roof of the hives, during 21 consecutive days, at the end of beekeeping season.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In honeybee colonies infected with Nosema ceranae, the number of N. ceranae spores per honeybee gradually decreased from Day 1 to Day 20 and Day 30 after initial feeding with BPC‑157-supplemented sugar syrup.

    In plain wordsIn honeybees, the number of Nosema spores per bee fell over 30 days after feeding with BPC‑157 syrup began.

    Peptide
    BPC-157
    Outcome
    DecreaseNosema ceranae spore load per honeybee
    Study

    Honeybee (Apis mellifera)n: not reported in source

    Honeybee colonies with Nosema ceranae invasion, apiary field conditions
    Comparator
    Day 1 (start of feeding)
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    0.1 μg/ml BPC 157 in sugar syrup (0.25 L) · Oral, in sugar syrup · 21 consecutive daysAs given in this study (Honeybee (Apis mellifera)).

    Measurements

    N. ceranae spore load
    6.286 million spores/bee
    Day 1 (± 2.336)
    N. ceranae spore load
    3.753 million spores/bee
    Day 20 (± 1.835)
    N. ceranae spore load
    2.005 million spores/bee
    Day 30 (± 1.534)

    Source sentences

    Summary
    The similar successful outcome occurs with the N. ceranae spore loads counted in the homogenates of sampled adult honeybees (Day 1, 6.286 ± 2.336; Day 20, 3.753 ± 1.835; Day 30, 2.005 ± 1.534 million spores/bee).
    1 context sentence
    Summary · context
    BPC 157 treated sugar syrup (0.25 L sugar syrup supplemented with 0.1 μg/ml BPC 157), as well as the pure sugar syrup (0.25 L sugar syrup; control), was administered to honeybee colonies in feeders situated under the roof of the hives, during 21 consecutive days, at the end of beekeeping season.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In honeybees infected with N. ceranae, midgut wall and epithelial cell damage, especially of the outer muscular coat, was markedly attenuated with BPC‑157-supplemented sugar syrup compared with sugar syrup alone.

    In plain wordsIn honeybees infected with Nosema, BPC‑157 syrup was followed by much less damage to the gut wall than plain sugar syrup.

    Peptide
    BPC-157
    Outcome
    DecreaseMidgut wall and epithelial cell damage
    Study

    Honeybee (Apis mellifera)n: not reported in source

    Honeybee colonies with Nosema ceranae invasion, apiary field conditions
    Comparator
    Infected honeybees fed sugar syrup without BPC 157
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    0.1 μg/ml BPC 157 in sugar syrup (0.25 L) · Oral, in sugar syrup · 21 consecutive daysAs given in this study (Honeybee (Apis mellifera)).

    Source sentences

    Summary
    Besides, honeybees infected with N. ceranae fed with sugar syrup exhibited severe damage of midgut wall layers and epithelial cells. By contrast, in honeybees infected with N. ceranae fed with sugar syrup supplemented with BPC 157, all damages were markedly attenuated, damages of the outer muscular coat, in particular.
    1 context sentence
    Summary · context
    BPC 157 treated sugar syrup (0.25 L sugar syrup supplemented with 0.1 μg/ml BPC 157), as well as the pure sugar syrup (0.25 L sugar syrup; control), was administered to honeybee colonies in feeders situated under the roof of the hives, during 21 consecutive days, at the end of beekeeping season.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 12:39 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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