In SW480 and HCT116 colorectal cancer cells, the mitochondria-targeted antioxidant SS31 and/or the cPLA2 inhibitor AACOCF3 abolished the ROS production, autophagy and apoptosis induced by IFN-γ.
In plain wordsIn colorectal cancer cells, SS31 and/or a cPLA2 inhibitor blocked the ROS, autophagy and cell death that interferon-gamma caused.
- Peptide
- Elamipretide (SS-31)
- Outcome
- Not applicableIFN-γ-induced ROS production, autophagy and apoptosis
- Study
n: not reported in source
SW480 and HCT116 colorectal cancer cell lines- Outcome group
- Tumor growth · Cancer
Source sentences
In addition, a mitochondria-targeted antioxidant SS31 and/or cPLA2 inhibitor AACOCF3 abolished the IFN-γ-induced ROS production and subsequent autophagy and apoptosis.
1 context sentence(design, population, supporting numbers)
We observed that IFN-γ induced mitochondria-derived reactive oxygen species (ROS) production in a time-dependent manner in SW480 and HCT116 cell lines.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).