Stimulation of growth hormone by kisspeptin antagonists in ewes.

Smith JT, Roseweir A, Millar M, Clarke IJ, Millar RP

The Journal of endocrinology16 Mar 2018Cited by 9 (Europe PMC)

PMID29549187DOI10.1530/joe-18-0074PepBankPUB-29549187

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ewes, central infusion of kisspeptin‑10 had no effect on growth hormone secretion.
In plain wordsIn ewes, kisspeptin‑10 given into the brain did not change growth hormone release.
Peptide
Kisspeptin-10
Outcome
No significant changeGH secretion after kisspeptin-10
Study
sheepn: not reported in source
Ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · central infusionAs given in this study (sheep).
Source sentences
Summary
Central infusion of kisspeptin-10 had no effect on GH secretion.
Report a problemFND-2954918701

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome
In ovariectomized or anestrous ewes, lateral or third ventricle infusion of the kisspeptin antagonists p-234 and p-271 clearly increased growth hormone secretion.
In plain wordsIn ewes, kisspeptin blockers given into the brain raised growth hormone release.
Peptide
Kisspeptin-10
Outcome
IncreaseGH secretion after kisspeptin antagonists p-234 and p-271
Study
sheepn: not reported in source
Ovariectomized or anestrous ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Our data show clear and robust increases in GH secretion following lateral ventricle or third ventricle infusion of kisspeptin antagonists p-234 and p-271 in either ovariectomized or anestrous ewes.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2954918702
03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In ewe pituitary cells, the majority of somatotropes expressed the kisspeptin receptor GPR54, while other pituitary cells were largely negative.
In plain wordsIn ewes, most growth hormone cells in the pituitary carry the kisspeptin receptor, while other pituitary cells mostly do not.
Peptide
Kisspeptin-10
Outcome
Not applicableGPR54 expression in somatotropes
Study
sheepn: not reported in source
Pituitary cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
To determine the level at which kisspeptin may influence GH secretion, we examined expression of the cognate kisspeptin receptor, GPR54, in pituitary cells and showed by immunocytochemistry that the majority of somatotropes express GPR54 while expression was largely negative in other pituitary cells.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2954918703

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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