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Study · Animal study (in vivo) · rat · 2018

10 results

Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157.

Vukojević J, Siroglavić M, Kašnik K, Kralj T, Stanćić D, Kokot A, Kolarić D, Drmić D, Sever AZ, Barišić I, Šuran J, Bojić D and 8 more

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Patrlj MH, Sjekavica I, Pavlov KH, Vidović T, Vlainić J, Stupnišek M, Seiwerth S, Sikirić P

Vascular pharmacology3 Mar 2018Cited by 58 (Europe PMC)

PMID29510201 (opens in a new tab)DOI10.1016/j.vph.2018.02.010 (opens in a new tab)PepBankPUB-29510201
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 counteracted direct vein injury.

    In plain wordsIn rats with a tied large vein, BPC‑157 reduced direct damage to the vein.

    Peptide
    BPC-157
    Outcome
    DecreaseDirect vein injury
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Organ injury · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Direct vein injury, thrombosis, thrombocytopenia, prolonged bleeding were all counteracted.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 counteracted thrombosis.

    In plain wordsIn rats with a tied large vein, BPC‑157 reduced blood clots.

    Peptide
    BPC-157
    Outcome
    DecreaseThrombosis
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Direct vein injury, thrombosis, thrombocytopenia, prolonged bleeding were all counteracted.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 counteracted thrombocytopenia.

    In plain wordsIn rats with a tied large vein, BPC‑157 reduced the fall in blood platelet numbers.

    Peptide
    BPC-157
    Outcome
    IncreaseThrombocytopenia
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Direct vein injury, thrombosis, thrombocytopenia, prolonged bleeding were all counteracted.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 counteracted prolonged bleeding.

    In plain wordsIn rats with a tied large vein, BPC‑157 reduced the longer bleeding time.

    Peptide
    BPC-157
    Outcome
    DecreaseProlonged bleeding
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Bleeding and clotting · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Direct vein injury, thrombosis, thrombocytopenia, prolonged bleeding were all counteracted.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with inferior caval vein ligation, BPC‑157 was followed by rapid presentation of collaterals and redistribution of otherwise trapped blood volume, bypassing through the left ovarian vein and other veins.

    In plain wordsIn rats with a tied large vein, BPC‑157 was followed by quick opening of side vessels that carried blood around the block.

    Peptide
    BPC-157
    Outcome
    IncreaseCollateral presentation and blood volume redistribution (bypass via left ovarian vein)
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Also, rapid presentation of collaterals and redistribution of otherwise trapped blood volume (bypassing through the left ovarian vein (LOV) and other veins), with venous hypertension, arterial hypotension and tachycardia counteraction were shown.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 counteracted venous hypertension and arterial hypotension.

    In plain wordsIn rats with a tied large vein, BPC‑157 reduced the abnormal high vein pressure and low artery pressure.

    Peptide
    BPC-157
    Outcome
    MixedVenous hypertension and arterial hypotension
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Also, rapid presentation of collaterals and redistribution of otherwise trapped blood volume (bypassing through the left ovarian vein (LOV) and other veins), with venous hypertension, arterial hypotension and tachycardia counteraction were shown.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 counteracted tachycardia.

    In plain wordsIn rats with a tied large vein, BPC‑157 reduced the fast heart rate.

    Peptide
    BPC-157
    Outcome
    DecreaseTachycardia
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Also, rapid presentation of collaterals and redistribution of otherwise trapped blood volume (bypassing through the left ovarian vein (LOV) and other veins), with venous hypertension, arterial hypotension and tachycardia counteraction were shown.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157-treated rats had raised plasma NO values but normal MDA values.

    In plain wordsIn rats with a tied large vein, BPC‑157-treated rats had raised nitric oxide in plasma but normal MDA values.

    Peptide
    BPC-157
    Outcome
    MixedPlasma NO and MDA values
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    BPC 157-rats presented raised plasma NO-values, but normal MDA-values;
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with inferior caval vein ligation, BPC‑157 reverted low NO values and counteracted increased MDA levels in ICV tissue.

    In plain wordsIn rats with a tied large vein, BPC‑157 raised low nitric oxide and lowered raised MDA in the vein tissue.

    Peptide
    BPC-157
    Outcome
    MixedICV tissue NO and MDA levels
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    in ICV tissue reverted low NO-values and counteracted increased MDA-levels.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with inferior caval vein ligation, altered expression of EGR, NOS, SRF, VEGFR and KRAS in ICV, ROV and LOV showed increased or decreased levels, while some genes remained unchanged.

    In plain wordsIn rats with a tied large vein, BPC‑157 was followed by higher or lower activity of some genes in the veins.

    Peptide
    BPC-157
    Outcome
    MixedGene expression of EGR, NOS, SRF, VEGFR and KRAS in ICV, ROV and LOV
    Study

    Ratsn: not reported in source

    Inferior caval vein (ICV) ligation up to the right ovarian vein
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    10 μg, 10 ng/kg (early regimen or delayed therapy)As given in this study (Rats).

    Source sentences

    Summary
    Altered expression of EGR, NOS, SRF, VEGFR and KRAS in ICV, ROV and LOV revealed increased or decreased levels, while some genes continuously remained unchanged.
    2 context sentences
    Summary · context
    Rat inferior caval vein (ICV) ligation (up to the right ovarian vein (ROV)) commonly represents a recapitulation of Virchow: with ligation leading to vessel injury, stasis, thrombosis and hemodynamic changes.
    Summary · context
    We applied BPC 157 (10 μg, 10 ng/kg) as an early regimen or as a delayed therapy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 12:39 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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