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Study · Animal study (in vivo) · rat · 2019

2 results

Increased Survival Time With SS-31 After Prolonged Cardiac Arrest in Rats.

Zhang W, Tam J, Shinozaki K, Yin T, Lampe JW, Becker LB, Kim J

Heart, lung & circulation7 Feb 2018Cited by 12 (Europe PMC)

PMID29503242 (opens in a new tab)PMCIDPMC6081272 (opens in a new tab)DOI10.1016/j.hlc.2018.01.008 (opens in a new tab)PepBankPUB-29503242
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats resuscitated after 25 minutes of cardiac arrest, more rats survived to 5 hours with SS‑31 than in controls.

    In plain wordsIn rats after cardiac arrest, more rats given SS‑31 survived to 5 hours than control rats.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSurvival at 5 hours after cardiac arrest
    Study

    ratn = 20

    Asphyxia-induced cardiac arrest with cardiopulmonary bypass resuscitation
    Comparator
    Control (resuscitation without SS-31)
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Rats surviving
    5 of 10
    SS-31 group
    Rats surviving
    1 of 10
    control group

    Source sentences

    Summary
    After 5hours, 5 of 10 rats survived in the SS-31 group whereas only 1 of 10 rats survived in the control group (p=0.026).
    1 context sentence
    Summary · context
    Rats were randomised into two groups. After 25minutes of asphyxia-induced cardiac arrest, rats were resuscitated with or without SS-31 using cardiopulmonary bypass resuscitation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats resuscitated after cardiac arrest, blood lactate at 90 minutes was lower with SS‑31 than in controls.

    In plain wordsIn rats after cardiac arrest, blood lactate was lower with SS‑31 than in control rats.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBlood lactate at 90 minutes after resuscitation
    Study

    ratn: not reported in source

    Asphyxia-induced cardiac arrest with cardiopulmonary bypass resuscitation
    Comparator
    Control (resuscitation without SS-31)
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    Blood lactate
    4.29 mmol/L
    SS-31 at 90 min
    Blood lactate
    7.36 mmol/L
    control at 90 min

    Source sentences

    Summary
    At 90minutes after resuscitation, the blood lactate level in the SS-31 treated rats (4.29±2.5mmol/L) was significantly lower than in control rats (7.36±3.1mmol/L, p=0.026), suggesting mitochondrial aerobic respiration was improved with SS-31 treatment.
    1 context sentence
    Summary · context
    Rats were randomised into two groups. After 25minutes of asphyxia-induced cardiac arrest, rats were resuscitated with or without SS-31 using cardiopulmonary bypass resuscitation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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