Skip to content

Study · In vitro (cells) · 2018

6 results

Thymosin β4 Reduces H₂O₂ Induced Oxidative Stress in MC3T3-E1 Cells on Titanium Surface.

Choi BD, Lim DS, Lee SY, Nho TH, Jeong SJ, Ko YM, Gang SN, Kim YJ, Piao XH, Jeong MJ

Journal of nanoscience and nanotechnology1 Feb 2018Cited by 6 (Europe PMC)

PMID29448512 (opens in a new tab)DOI10.1166/jnn.2018.14865 (opens in a new tab)PepBankPUB-29448512
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs, Tβ4 increased cell proliferation.

    In plain wordsIn cells, Tβ4 increased the growth of bone-forming cells stressed by hydrogen peroxide on titanium.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseProliferation of H2O2-exposed cells
    Study

    n: not reported in source

    H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Based on an MTT assay and bromodeoxyuridine immunofluorescence staining, Tβ4 was found to increase the proliferation of the H2O2-exposed MC3T3-E1 cells on Ti discs.
    1 context sentence
    Summary · context
    Thus, the aim of this study was to determine the biological effects of Tβ4 on the oxidative stress induced to MC3T3-E1 preosteoblasts on the Ti surface.
  2. 02LabIn vitro (cells)Mechanism

    In H2O2-exposed MC3T3-E1 cells on titanium discs, Tβ4 decreased the mRNA and protein expression of iNOS.

    In plain wordsIn cells, Tβ4 lowered the amount of iNOS, an inflammation-related enzyme, in stressed bone-forming cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseiNOS mRNA and protein expression
    Study

    n: not reported in source

    H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Reverse transcription-polymerase chain reaction and western blot analyses showed that Tβ4 decreased the mRNA and protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in H2O2-exposed MC3T3-E1 cells on the Ti discs.
    1 context sentence
    Summary · context
    Thus, the aim of this study was to determine the biological effects of Tβ4 on the oxidative stress induced to MC3T3-E1 preosteoblasts on the Ti surface.
  3. 03LabIn vitro (cells)Mechanism

    In H2O2-exposed MC3T3-E1 cells on titanium discs, Tβ4 decreased the mRNA and protein expression of COX-2.

    In plain wordsIn cells, Tβ4 lowered the amount of COX-2, an inflammation-related enzyme, in stressed bone-forming cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCOX-2 mRNA and protein expression
    Study

    n: not reported in source

    H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Reverse transcription-polymerase chain reaction and western blot analyses showed that Tβ4 decreased the mRNA and protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in H2O2-exposed MC3T3-E1 cells on the Ti discs.
    1 context sentence
    Summary · context
    Thus, the aim of this study was to determine the biological effects of Tβ4 on the oxidative stress induced to MC3T3-E1 preosteoblasts on the Ti surface.
  4. 04LabIn vitro (cells)Mechanism

    In H2O2-exposed MC3T3-E1 cells on titanium discs, Tβ4 inhibited the synthesis of intracellular ROS.

    In plain wordsIn cells, Tβ4 reduced the production of reactive oxygen species in stressed bone-forming cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseIntracellular ROS synthesis
    Study

    n: not reported in source

    H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs
    Outcome group
    Oxidative stress · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 inhibited the synthesis of intracellular ROS and the secretion of NO and prostaglandin E2 (PGE2) from H2O2-exposed MC3T3-E1 cells on the Ti discs.
    1 context sentence
    Summary · context
    Thus, the aim of this study was to determine the biological effects of Tβ4 on the oxidative stress induced to MC3T3-E1 preosteoblasts on the Ti surface.
  5. 05LabIn vitro (cells)Mechanism

    In H2O2-exposed MC3T3-E1 cells on titanium discs, Tβ4 inhibited the secretion of nitric oxide.

    In plain wordsIn cells, Tβ4 reduced nitric oxide release from stressed bone-forming cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNitric oxide secretion
    Study

    n: not reported in source

    H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 inhibited the synthesis of intracellular ROS and the secretion of NO and prostaglandin E2 (PGE2) from H2O2-exposed MC3T3-E1 cells on the Ti discs.
    1 context sentence
    Summary · context
    Thus, the aim of this study was to determine the biological effects of Tβ4 on the oxidative stress induced to MC3T3-E1 preosteoblasts on the Ti surface.
  6. 06LabIn vitro (cells)Mechanism

    In H2O2-exposed MC3T3-E1 cells on titanium discs, Tβ4 inhibited the secretion of prostaglandin E2.

    In plain wordsIn cells, Tβ4 reduced prostaglandin E2 release from stressed bone-forming cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseProstaglandin E2 secretion
    Study

    n: not reported in source

    H2O2-exposed MC3T3-E1 preosteoblasts on titanium discs
    Outcome group
    Inflammation markers · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 inhibited the synthesis of intracellular ROS and the secretion of NO and prostaglandin E2 (PGE2) from H2O2-exposed MC3T3-E1 cells on the Ti discs.
    1 context sentence
    Summary · context
    Thus, the aim of this study was to determine the biological effects of Tβ4 on the oxidative stress induced to MC3T3-E1 preosteoblasts on the Ti surface.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.