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Study · Randomized controlled trial · n = 90 · 2018

6 results

Effect of Prolonged GnRH Agonist Downregulation on ICSI Outcome in Patients With Endometriomas of Less Than 5 cm: A Randomized Controlled Trial.

Maged AM, Rashwan H, Mahmoud M, El-Mazny A, Farouk M, Belal DS, Marie HM

Reproductive sciences (Thousand Oaks, Calif.)13 Feb 2018Cited by 10 (Europe PMC)

PMID29439618 (opens in a new tab)DOI10.1177/1933719118756753 (opens in a new tab)PepBankPUB-29439618
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with small endometriomas, prolonged triptorelin did not significantly change retrieved oocyte counts versus the standard protocol.

    In plain wordsIn patients with small endometriomas, prolonged triptorelin did not significantly change retrieved oocyte counts versus the standard protocol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeRetrieved oocyte count
    Study

    n = 90

    Comparator
    Standard long protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg, three injections 28 days apart · intramuscularAs given in this study (human).

    Source sentences

    Summary
    All ICSI cycle characteristics including number of retrieved oocytes, fertilized oocytes, and transferred embryos were also not significantly different.
    2 context sentences
    Summary · context
    In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups.
    Summary · context
    Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with small endometriomas, prolonged triptorelin did not significantly change fertilized oocyte counts versus the standard protocol.

    In plain wordsIn patients with small endometriomas, prolonged triptorelin did not significantly change fertilized oocyte counts versus the standard protocol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFertilized oocyte count
    Study

    n = 90

    Comparator
    Standard long protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg, three injections 28 days apart · intramuscularAs given in this study (human).

    Source sentences

    Summary
    All ICSI cycle characteristics including number of retrieved oocytes, fertilized oocytes, and transferred embryos were also not significantly different.
    2 context sentences
    Summary · context
    In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups.
    Summary · context
    Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In patients with small endometriomas, prolonged triptorelin did not significantly change transferred embryo counts versus the standard protocol.

    In plain wordsIn patients with small endometriomas, prolonged triptorelin did not significantly change transferred embryo counts versus the standard protocol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeTransferred embryo count
    Study

    n = 90

    Comparator
    Standard long protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg, three injections 28 days apart · intramuscularAs given in this study (human).

    Source sentences

    Summary
    All ICSI cycle characteristics including number of retrieved oocytes, fertilized oocytes, and transferred embryos were also not significantly different.
    2 context sentences
    Summary · context
    In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups.
    Summary · context
    Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In patients with small endometriomas, prolonged triptorelin increased chemical pregnancy rates versus the standard protocol.

    In plain wordsIn patients with small endometriomas, prolonged triptorelin increased chemical pregnancy rates versus the standard protocol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseChemical pregnancy rate
    Study

    n = 90

    Comparator
    Standard long protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg, three injections 28 days apart · intramuscularAs given in this study (human).

    Source sentences

    Summary
    However, patients who received prolonged GnRH agonist therapy showed significantly higher chemical ( P = .011), clinical ( P = .018), and ongoing ( P = .028) pregnancy rates.
    2 context sentences
    Summary · context
    In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups.
    Summary · context
    Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In patients with small endometriomas, prolonged triptorelin increased clinical pregnancy rates versus the standard protocol.

    In plain wordsIn patients with small endometriomas, prolonged triptorelin increased clinical pregnancy rates versus the standard protocol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseClinical pregnancy rate
    Study

    n = 90

    Comparator
    Standard long protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg, three injections 28 days apart · intramuscularAs given in this study (human).

    Source sentences

    Summary
    However, patients who received prolonged GnRH agonist therapy showed significantly higher chemical ( P = .011), clinical ( P = .018), and ongoing ( P = .028) pregnancy rates.
    2 context sentences
    Summary · context
    In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups.
    Summary · context
    Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In patients with small endometriomas, prolonged triptorelin increased ongoing pregnancy rates versus the standard protocol.

    In plain wordsIn patients with small endometriomas, prolonged triptorelin increased ongoing pregnancy rates versus the standard protocol.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseOngoing pregnancy rate
    Study

    n = 90

    Comparator
    Standard long protocol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg, three injections 28 days apart · intramuscularAs given in this study (human).

    Source sentences

    Summary
    However, patients who received prolonged GnRH agonist therapy showed significantly higher chemical ( P = .011), clinical ( P = .018), and ongoing ( P = .028) pregnancy rates.
    2 context sentences
    Summary · context
    In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups.
    Summary · context
    Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3.75 mg 28 days apart followed by the standard long protocol 28 days after the last injection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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