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Study · Not a test of the peptide alone · 2018

2 results

Dual trigger of triptorelin and HCG optimizes clinical outcome for high ovarian responder in GnRH-antagonist protocols.

Li S, Zhou D, Yin T, Xu W, Xie Q, Cheng D, Yang J

Oncotarget4 Jan 2018Cited by 14 (Europe PMC)

Summary

In this paper, a retrospective cohort study was conducted to the high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles. The purpose of the study is to investigate whether dual triggering of final oocyte maturation with a combination of gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin (HCG) can improve the clinical outcome compared with traditional dose (10000IU) HCG trigger and low-dose (8000IU) HCG trigger for high ovarian responders in GnRH-antagonist in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI) cycles. Our study included 226 couples with high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles. Standard dosage of HCG trigger (10000 IU of recombinant HCG) versus dual trigger (0.2 mg of triptorelin and 2000 IU of recombinant HCG) and low-dose HCG trigger (8000IU of recombinant HCG) were used for final oocyte maturation. Our main outcome measures were high quality embryo rate, the number of usable embryos, the risk of OHSS, duration of hospitalization and incidence rate of complications. Our evidence demonstrated that dual trigger is capable of preventing severe OHSS while still maintaining excellent high quality embryo rate in in high ovarian responders of GnRH-antagonist protocols.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studySafety outcome

    In high ovarian responders, a dual trigger of triptorelin plus HCG was associated with prevention of severe ovarian hyperstimulation syndrome compared with standard-dose or low-dose HCG trigger.

    In plain wordsIn high ovarian responders, a dual trigger of triptorelin plus HCG was linked to prevention of severe ovarian hyperstimulation syndrome compared with HCG-only triggers.

    Outcome
    DecreaseSevere ovarian hyperstimulation syndrome
    Study

    n = 226

    Comparator
    Standard-dose (10000 IU) HCG trigger and low-dose (8000 IU) HCG trigger
    Outcome group
    Adverse events · Reproductive and sexual health

    Source sentences

    Summary
    Our evidence demonstrated that dual trigger is capable of preventing severe OHSS while still maintaining excellent high quality embryo rate in in high ovarian responders of GnRH-antagonist protocols.
    3 context sentences
    Summary · context
    In this paper, a retrospective cohort study was conducted to the high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles.
    Summary · context
    Standard dosage of HCG trigger (10000 IU of recombinant HCG) versus dual trigger (0.2 mg of triptorelin and 2000 IU of recombinant HCG) and low-dose HCG trigger (8000IU of recombinant HCG) were used for final oocyte maturation.
    Summary · context
    Our study included 226 couples with high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome

    In high ovarian responders, a dual trigger of triptorelin plus HCG was associated with maintenance of a high-quality embryo rate compared with standard-dose or low-dose HCG trigger.

    In plain wordsIn high ovarian responders, a dual trigger of triptorelin plus HCG was linked to maintaining a high-quality embryo rate compared with HCG-only triggers.

    Outcome
    Not applicableHigh quality embryo rate
    Study

    n = 226

    Comparator
    Standard-dose (10000 IU) HCG trigger and low-dose (8000 IU) HCG trigger
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Our evidence demonstrated that dual trigger is capable of preventing severe OHSS while still maintaining excellent high quality embryo rate in in high ovarian responders of GnRH-antagonist protocols.
    3 context sentences
    Summary · context
    In this paper, a retrospective cohort study was conducted to the high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles.
    Summary · context
    Standard dosage of HCG trigger (10000 IU of recombinant HCG) versus dual trigger (0.2 mg of triptorelin and 2000 IU of recombinant HCG) and low-dose HCG trigger (8000IU of recombinant HCG) were used for final oocyte maturation.
    Summary · context
    Our study included 226 couples with high ovarian responders in GnRH-antagonist protocols of IVF/ICSI cycles.

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownNot applicableNCT04717752

A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve

Nanjing Universityn = 310est. 20 Jan 2021 to est. 31 Dec 2021

Poor Ovarian Response

Trial pageClinicalTrials.govUpdated 28 Jan 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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