Humanin promotes mitochondrial biogenesis in pancreatic MIN6 β-cells.

Qin Q, Jin J, He F, Zheng Y, Li T, Zhang Y, He J

Biochemical and biophysical research communications10 Feb 2018Cited by 41 (Europe PMC)

PMID29432738DOI10.1016/j.bbrc.2018.02.071PepBankPUB-29432738

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment significantly increased the expression of PGC-1alpha and its target genes NRF1 and TFAM.
In plain wordsIn pancreatic beta-cells, humanin raised the activity of genes that drive new mitochondria.
Peptide
Humanin
Outcome
IncreasePGC-1alpha, NRF1 and TFAM expression
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Our findings demonstrated that Humanin treatment significantly increased the expression of PGC-1α and its downstream target genes NRF1 and TFAM in MIN6 β-cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273801
02LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment increased mitochondrial mass.
In plain wordsIn pancreatic beta-cells, humanin increased the amount of mitochondria.
Peptide
Humanin
Outcome
IncreaseMitochondrial mass
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Notably, Humanin treatment significantly promoted mitochondrial biogenesis by increasing mitochondrial mass, elevating mtDNA/nDNA ratio, and stimulating the expression of cytochrome B, which were suppressed by the specific AMPK inhibitor compound C.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273802
03LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment elevated the mtDNA/nDNA ratio.
In plain wordsIn pancreatic beta-cells, humanin raised the ratio of mitochondrial DNA to nuclear DNA.
Peptide
Humanin
Outcome
IncreasemtDNA/nDNA ratio
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Notably, Humanin treatment significantly promoted mitochondrial biogenesis by increasing mitochondrial mass, elevating mtDNA/nDNA ratio, and stimulating the expression of cytochrome B, which were suppressed by the specific AMPK inhibitor compound C.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273803
04LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment stimulated the expression of cytochrome B.
In plain wordsIn pancreatic beta-cells, humanin raised the expression of a mitochondrial gene, cytochrome B.
Peptide
Humanin
Outcome
IncreaseCytochrome B expression
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Notably, Humanin treatment significantly promoted mitochondrial biogenesis by increasing mitochondrial mass, elevating mtDNA/nDNA ratio, and stimulating the expression of cytochrome B, which were suppressed by the specific AMPK inhibitor compound C.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273804
05LabIn vitro (cells)Mechanism
In MIN6 beta-cells, the increases in mitochondrial mass, mtDNA/nDNA ratio and cytochrome B after Humanin were suppressed by the AMPK inhibitor compound C.
In plain wordsIn pancreatic beta-cells, blocking AMPK with compound C suppressed the humanin-driven rise in mitochondrial markers.
Peptide
Humanin
Outcome
No significant changeHumanin effects under AMPK inhibitor compound C
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Notably, Humanin treatment significantly promoted mitochondrial biogenesis by increasing mitochondrial mass, elevating mtDNA/nDNA ratio, and stimulating the expression of cytochrome B, which were suppressed by the specific AMPK inhibitor compound C.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273805
06LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment caused phosphorylation of AMPK, which was involved in the induction of PGC-1alpha, NRF1 and TFAM.
In plain wordsIn pancreatic beta-cells, humanin switched on AMPK, which helped raise genes that build mitochondria.
Peptide
Humanin
Outcome
IncreaseAMPK phosphorylation
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Indeed, Humanin treatment caused the phosphorylation of AMPK, which was involved in the induction of PGC-1α, NRF1, and TFAM by Humanin.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273806
07LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment increased ATP levels.
In plain wordsIn pancreatic beta-cells, humanin increased ATP, the cell's energy molecule.
Peptide
Humanin
Outcome
IncreaseATP levels
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Importantly, our findings indicate that Humanin treatment led to a possible functional gain of the mitochondria by increasing ATP levels and respiratory rate.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273807
08LabIn vitro (cells)Mechanism
In MIN6 beta-cells, Humanin treatment increased the respiratory rate.
In plain wordsIn pancreatic beta-cells, humanin increased how fast cells consumed oxygen.
Peptide
Humanin
Outcome
IncreaseRespiratory rate
Study
n: not reported in source
MIN6 pancreatic beta-cells
Outcome group
Mitochondrial function · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Importantly, our findings indicate that Humanin treatment led to a possible functional gain of the mitochondria by increasing ATP levels and respiratory rate.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, we aimed to define the effects of Humanin on mitochondrial biogenesis in pancreatic β-cells.
Report a problemFND-2943273808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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