NAD⁺ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

Hou Y, Lautrup S, Cordonnier S, Wang Y, Croteau DL, Zavala E, Zhang Y, Moritoh K, O'Connell JF, Baptiste BA, Stevnsner TV, Mattson MP, Bohr VA

Proceedings of the National Academy of Sciences of the United States of America5 Feb 2018Cited by 428 (Europe PMC)

PMID29432159PMCIDPMC5828618DOI10.1073/pnas.1718819115PepBankPUB-29432159

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In 3xTgAD/Polβ+/- mice, the natural cerebral NAD+/NADH ratio was reduced.
In plain wordsIn AD-model mice with DNA repair deficiency, the natural brain NAD+/NADH ratio was reduced.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseCerebral NAD+/NADH ratio
Study
mousen: not reported in source
3xTgAD/Polβ+/- mice
Outcome group
Mitochondrial function · Nervous system and cognition
Source sentences
Summary
Here we report that 3xTgAD/Polβ^+/- mice have a reduced cerebral NAD⁺/NADH ratio indicating impaired cerebral energy metabolism, which is normalized by nicotinamide riboside (NR) treatment.
This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2943215901
02AnimalEndogenous levelAnimal study (in vivo)Other
In 3xTgAD/Polβ+/- mice, NR normalized the reduced natural cerebral NAD+/NADH ratio.
In plain wordsIn AD-model mice with DNA repair deficiency, NR normalized the reduced natural brain NAD+/NADH ratio.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseCerebral NAD+/NADH normalization
Study
mousen: not reported in source
3xTgAD/Polβ+/- mice
Outcome group
Mitochondrial function · Nervous system and cognition
Source sentences
Summary
Here we report that 3xTgAD/Polβ^+/- mice have a reduced cerebral NAD⁺/NADH ratio indicating impaired cerebral energy metabolism, which is normalized by nicotinamide riboside (NR) treatment.
This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2943215902

Studies that did not test the peptide alone9

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

03AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In both AD mouse models, the NAD+ precursor NR lessened pTau pathology.
In plain wordsIn both AD mouse models, the NAD+ precursor NR reduced pTau pathology.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreasepTau pathology
Study
mousen: not reported in source
3xTgAD and 3xTgAD/Polβ+/- mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
NR lessened pTau pathology in both 3xTgAD and 3xTgAD/Polβ^+/- mice but had no impact on amyloid β peptide (Aβ) accumulation.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215903
04AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In both AD mouse models, the NAD+ precursor NR had no impact on amyloid beta accumulation.
In plain wordsIn both AD mouse models, the NAD+ precursor NR did not change amyloid beta accumulation.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Direction not reportedAmyloid beta accumulation
Study
mousen: not reported in source
3xTgAD and 3xTgAD/Polβ+/- mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
NR lessened pTau pathology in both 3xTgAD and 3xTgAD/Polβ^+/- mice but had no impact on amyloid β peptide (Aβ) accumulation.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215904
05AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In DNA repair-deficient AD mice, the NAD+ precursor NR reduced DNA damage.
In plain wordsIn AD-model mice with DNA repair deficiency, the NAD+ precursor NR reduced DNA damage.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseDNA damage
Study
mousen: not reported in source
3xTgAD/Polβ+/- mice
Outcome group
Aging markers · Nervous system and cognition
Source sentences
Summary
NR-treated 3xTgAD/Polβ^+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215905
06AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In DNA repair-deficient AD mice, the NAD+ precursor NR reduced neuroinflammation.
In plain wordsIn AD-model mice with DNA repair deficiency, the NAD+ precursor NR reduced brain inflammation.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseNeuroinflammation
Study
mousen: not reported in source
3xTgAD/Polβ+/- mice
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
NR-treated 3xTgAD/Polβ^+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215906
07AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In DNA repair-deficient AD mice, the NAD+ precursor NR reduced hippocampal neuron apoptosis.
In plain wordsIn AD-model mice with DNA repair deficiency, the NAD+ precursor NR reduced hippocampal neuron death.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseHippocampal neuron apoptosis
Study
mousen: not reported in source
3xTgAD/Polβ+/- mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
NR-treated 3xTgAD/Polβ^+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215907
08AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Mechanism
In DNA repair-deficient AD mice, the NAD+ precursor NR increased brain SIRT3 activity.
In plain wordsIn AD-model mice with DNA repair deficiency, the NAD+ precursor NR increased brain SIRT3 activity.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseBrain SIRT3 activity
Study
mousen: not reported in source
3xTgAD/Polβ+/- mice
Outcome group
Mitochondrial function · Nervous system and cognition
Source sentences
Summary
NR-treated 3xTgAD/Polβ^+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215908
09AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In both AD mouse models, the NAD+ precursor NR improved cognitive function in multiple behavioral tests.
In plain wordsIn both AD mouse models, the NAD+ precursor NR improved cognitive function in several behavioral tests.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseCognitive function
Study
mousen: not reported in source
3xTgAD and 3xTgAD/Polβ+/- mice
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
NR improved cognitive function in multiple behavioral tests and restored hippocampal synaptic plasticity in 3xTgAD mice and 3xTgAD/Polβ^+/- mice.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215909
10AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
In both AD mouse models, the NAD+ precursor NR restored hippocampal synaptic plasticity.
In plain wordsIn both AD mouse models, the NAD+ precursor NR restored hippocampal synaptic plasticity.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseHippocampal synaptic plasticity
Study
mousen: not reported in source
3xTgAD and 3xTgAD/Polβ+/- mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
NR improved cognitive function in multiple behavioral tests and restored hippocampal synaptic plasticity in 3xTgAD mice and 3xTgAD/Polβ^+/- mice.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215910
11AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome
NAD+ precursor NR benefits were generally greater in DNA repair-deficient AD mice than in 3xTgAD mice.
In plain wordsIn mice, NAD+ precursor NR benefits were generally greater with DNA repair deficiency than in 3xTgAD mice.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseGenotype-dependent benefits
Study
mousen: not reported in source
3xTgAD and 3xTgAD/Polβ+/- mice
Comparator
3xTgAD mice
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
In general, the deficits between genotypes and the benefits of NR were greater in 3xTgAD/Polβ^+/- mice than in 3xTgAD mice.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-2943215911

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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