[A neuroprotective action of carnosine in conditions of experimental focal cerebral ischemia-reperfusion].

Stvolinsky SL, Fedorova TN, Devyatov AA, Medvedev OS, Belousova MA, Ryzhkov IN, Tutelyan VA

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2017Cited by 5 (Europe PMC)

PMID29411747DOI10.17116/jnevro201711712260-64PepBankPUB-29411747

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia-reperfusion, preventive carnosine decreased lesion size by 20% versus controls.
In plain wordsIn rats with brain ischemia, preventive carnosine reduced lesion size by 20% compared with controls.
Peptide
L-carnosine
Outcome
DecreaseLesion size
Study
ratn: not reported in source
Wistar rats with focal cerebral ischemia-reperfusion
Comparator
Control animals
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
150 mg/kg/day · mixed with ration · 7 days before surgeryAs given in this study (rat).
Measurements
Lesion size reduction
20%
versus control
Source sentences
Summary
Carnosine decreased the size of the lesion by 20%, neurological deficit by 43% with a simultaneous increase in the antioxidant status of blood plasma and brain tissue compared to the animals of the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
A focal ischemia in Wistar rats induced by the 60 min-occlusion of the middle cerebral artery with the following 24h-reperfusion was used.
Summary · context
Animals received carnosine mixed with ration in daily dose of 150 mg/kg of body mass during 7 days before surgery.
Report a problemFND-2941174701
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia-reperfusion, preventive carnosine decreased neurological deficit by 43% versus controls.
In plain wordsIn rats with brain ischemia, preventive carnosine reduced neurological deficits by 43% compared with controls.
Peptide
L-carnosine
Outcome
DecreaseNeurological deficit
Study
ratn: not reported in source
Wistar rats with focal cerebral ischemia-reperfusion
Comparator
Control animals
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
150 mg/kg/day · mixed with ration · 7 days before surgeryAs given in this study (rat).
Measurements
Neurological deficit reduction
43%
versus control
Source sentences
Summary
Carnosine decreased the size of the lesion by 20%, neurological deficit by 43% with a simultaneous increase in the antioxidant status of blood plasma and brain tissue compared to the animals of the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
A focal ischemia in Wistar rats induced by the 60 min-occlusion of the middle cerebral artery with the following 24h-reperfusion was used.
Summary · context
Animals received carnosine mixed with ration in daily dose of 150 mg/kg of body mass during 7 days before surgery.
Report a problemFND-2941174702
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia-reperfusion, preventive carnosine increased blood plasma antioxidant status versus controls.
In plain wordsIn rats with brain ischemia, preventive carnosine increased blood plasma antioxidant status compared with controls.
Peptide
L-carnosine
Outcome
IncreasePlasma antioxidant status
Study
ratn: not reported in source
Wistar rats with focal cerebral ischemia-reperfusion
Comparator
Control animals
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg/day · mixed with ration · 7 days before surgeryAs given in this study (rat).
Source sentences
Summary
Carnosine decreased the size of the lesion by 20%, neurological deficit by 43% with a simultaneous increase in the antioxidant status of blood plasma and brain tissue compared to the animals of the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
A focal ischemia in Wistar rats induced by the 60 min-occlusion of the middle cerebral artery with the following 24h-reperfusion was used.
Summary · context
Animals received carnosine mixed with ration in daily dose of 150 mg/kg of body mass during 7 days before surgery.
Report a problemFND-2941174703
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with cerebral ischemia-reperfusion, preventive carnosine increased brain tissue antioxidant status versus controls.
In plain wordsIn rats with brain ischemia, preventive carnosine increased brain antioxidant status compared with controls.
Peptide
L-carnosine
Outcome
IncreaseBrain antioxidant status
Study
ratn: not reported in source
Wistar rats with focal cerebral ischemia-reperfusion
Comparator
Control animals
Outcome group
Oxidative stress · Nervous system and cognition
Studied dose
150 mg/kg/day · mixed with ration · 7 days before surgeryAs given in this study (rat).
Source sentences
Summary
Carnosine decreased the size of the lesion by 20%, neurological deficit by 43% with a simultaneous increase in the antioxidant status of blood plasma and brain tissue compared to the animals of the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
A focal ischemia in Wistar rats induced by the 60 min-occlusion of the middle cerebral artery with the following 24h-reperfusion was used.
Summary · context
Animals received carnosine mixed with ration in daily dose of 150 mg/kg of body mass during 7 days before surgery.
Report a problemFND-2941174704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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