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Study · Animal study (in vivo) · mouse · 2018

4 results

Impact of Triclosan on Female Reproduction through Reducing Thyroid Hormones to Suppress Hypothalamic Kisspeptin Neurons in Mice.

Cao XY, Hua X, Xiong JW, Zhu WT, Zhang J, Chen L

Frontiers in molecular neuroscience19 Jan 2018Cited by 31 (Europe PMC)

PMID29403355 (opens in a new tab)PMCIDPMC5780345 (opens in a new tab)DOI10.3389/fnmol.2018.00006 (opens in a new tab)PepBankPUB-29403355
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Summary

Triclosan (TCS), a broad-spectrum antimicrobial agent, is widely used in clinical settings and various personal care products. The aim of this study was to evaluate the influence of TCS on reproductive endocrine and function. Here, we show that the exposure of adult female mice to 10 or 100 mg/kg/day TCS caused prolongation of diestrus, and decreases in antral follicles and corpora lutea within 2 weeks. TCS mice showed decreases in the levels of serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and progesterone, and gonadotrophin-releasing hormone (GnRH) mRNA with the lack of LH surge and elevation of prolactin (PRL). TCS mice had lower kisspeptin immunoreactivity and kiss1 mRNA in anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC). Moreover, the estrogen (E2)-enhanced AVPV-kisspeptin expression was reduced in TCS mice. In addition, the serum thyroid hormones (triiodothyronine (T3) and thyroxine (T4)) in TCS mice were reduced with increases in levels of thyroid stimulating hormone (TSH) and thyroid releasing hormone (TRH). In TCS mice, the treatment with Levothyroxine (L-T4) corrected the increases in PRL, TSH and TRH; the administration of L-T4 or type-2 dopamine receptors agonist quinpirole inhibiting PRL release could rescue the decline of kisspeptin expression in AVPV and ARC; the treatment with L-T4, quinpirole or the GPR45 agonist kisspeptin-10 recovered the levels of serum LH and FSH and progesterone, and GnRH mRNA. Furthermore, TCS mice treated with L-T4 or quinpirole resumed regular estrous cycling, follicular development and ovulation. Together, these results indicate that exposing adult female mice to TCS (≥10 mg/kg) reduces thyroid hormones causing hyperprolactinemia that then suppresses hypothalamic kisspeptin expression, leading to deficits in reproductive endocrine and function.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In triclosan-exposed female mice, kisspeptin‑10 treatment recovered serum LH levels.

    In plain wordsIn mice with triclosan-lowered hormones, kisspeptin‑10 restored LH levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum LH recovery
    Study

    mousen: not reported in source

    Adult female mice exposed to triclosan
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the treatment with L-T4, quinpirole or the GPR45 agonist kisspeptin-10 recovered the levels of serum LH and FSH and progesterone, and GnRH mRNA.
    1 context sentence
    Summary · context
    Here, we show that the exposure of adult female mice to 10 or 100 mg/kg/day TCS caused prolongation of diestrus, and decreases in antral follicles and corpora lutea within 2 weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In triclosan-exposed female mice, kisspeptin‑10 treatment recovered serum FSH levels.

    In plain wordsIn mice with triclosan-lowered hormones, kisspeptin‑10 restored FSH levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum FSH recovery
    Study

    mousen: not reported in source

    Adult female mice exposed to triclosan
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the treatment with L-T4, quinpirole or the GPR45 agonist kisspeptin-10 recovered the levels of serum LH and FSH and progesterone, and GnRH mRNA.
    1 context sentence
    Summary · context
    Here, we show that the exposure of adult female mice to 10 or 100 mg/kg/day TCS caused prolongation of diestrus, and decreases in antral follicles and corpora lutea within 2 weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In triclosan-exposed female mice, kisspeptin‑10 treatment recovered serum progesterone levels.

    In plain wordsIn mice with triclosan-lowered hormones, kisspeptin‑10 restored progesterone levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum progesterone recovery
    Study

    mousen: not reported in source

    Adult female mice exposed to triclosan
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the treatment with L-T4, quinpirole or the GPR45 agonist kisspeptin-10 recovered the levels of serum LH and FSH and progesterone, and GnRH mRNA.
    1 context sentence
    Summary · context
    Here, we show that the exposure of adult female mice to 10 or 100 mg/kg/day TCS caused prolongation of diestrus, and decreases in antral follicles and corpora lutea within 2 weeks.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In triclosan-exposed female mice, kisspeptin‑10 treatment recovered GnRH mRNA levels.

    In plain wordsIn mice with triclosan-lowered hormones, kisspeptin‑10 restored GnRH gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGnRH mRNA recovery
    Study

    mousen: not reported in source

    Adult female mice exposed to triclosan
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the treatment with L-T4, quinpirole or the GPR45 agonist kisspeptin-10 recovered the levels of serum LH and FSH and progesterone, and GnRH mRNA.
    1 context sentence
    Summary · context
    Here, we show that the exposure of adult female mice to 10 or 100 mg/kg/day TCS caused prolongation of diestrus, and decreases in antral follicles and corpora lutea within 2 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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