In rats with cardiac ischemia-reperfusion injury, HNG at 168 and 252 ug/kg during ischemia, and 252 ug/kg at reperfusion onset, attenuated brain mitochondrial dysfunction.
In plain wordsIn rats with induced heart injury, a humanin analogue reduced brain mitochondrial damage compared with vehicle.
- Peptide
- Humanin
- Outcome
- DecreaseBrain mitochondrial dysfunction
- Study
ratn: not reported in source
Cardiac ischemia-reperfusion injury in male Wistar rats- Comparator
- Vehicle
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 84, 168 and 252 ug/kg HNG · intravenousAs given in this study (rat).
Source sentences
HNG at a dose of 168 and 252 μg/kg administered during ischemia, and 252 μg/kg given at the onset of reperfusion effectively attenuated the brain mitochondrial dysfunction, tau hyperphosphorylation and Aβ accumulation, and apoptosis, without reducing BBB breakdown, brain oxidative stress, or mitocho…
2 context sentences(design, population, supporting numbers)
Thirty-six male Wistar rats were divided into two groups: a cardiac I/R group (n = 30), and a sham group (n = 6).
The I/R rats were then divided into five subgroups to receive: 1) vehicle; 2) HNG (84 μg/kg); 3) HNG (168 μg/kg); 4) HNG (252 μg/kg) intravenously administered during the cardiac-ischemia; and 5) HNG at 252 μg/kg given at the onset of reperfusion.