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Study · Animal study (in vivo) · rat · 2018

3 results

Diaphragmatic dysfunction in sepsis due to severe acute pancreatitis complicated by intra-abdominal hypertension.

Liao WC, Chen YH, Li HY, Wang TT, Lan P, Pan KH, Ge HQ, Xie QM, Zhou JC

The Journal of international medical research29 Jan 2018Cited by 10 (Europe PMC)

PMID29376467 (opens in a new tab)PMCIDPMC6091837 (opens in a new tab)DOI10.1177/0300060517747163 (opens in a new tab)PepBankPUB-29376467
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In septic rats with severe acute pancreatitis and intra-abdominal hypertension, SS‑31 reversed myofibre atrophy in the diaphragm.

    In plain wordsIn septic rats, SS‑31 reversed shrinkage of diaphragm muscle fibres.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm myofibre atrophy
    Study

    ratn = 5

    Septic rat model of severe acute pancreatitis with intra-abdominal hypertension
    Comparator
    SAP+IAH rats
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, SS-31 could reverse atrophy of myofibres in SAP+IAH rats
    1 context sentence
    Summary · context
    Methods The rats were assigned at random to four groups: (1) control (n = 5), (2) SAP (n = 5), (3) SAP+IAH (n = 5), and (4) SAP+IAH+SS-31 (n = 5).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In septic rats with severe acute pancreatitis and intra-abdominal hypertension, SS‑31 reversed contractile dysfunction of the diaphragm.

    In plain wordsIn septic rats, SS‑31 reversed weak contraction of the diaphragm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseDiaphragm contractile function
    Study

    ratn = 5

    Septic rat model of severe acute pancreatitis with intra-abdominal hypertension
    Comparator
    SAP+IAH rats
    Outcome group
    Muscle injury and repair · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, SS-31 could reverse atrophy of myofibres in SAP+IAH rats, as well as contractile dysfunction and mitochondrial dysfunction in the diaphragm.
    1 context sentence
    Summary · context
    Methods The rats were assigned at random to four groups: (1) control (n = 5), (2) SAP (n = 5), (3) SAP+IAH (n = 5), and (4) SAP+IAH+SS-31 (n = 5).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In septic rats with severe acute pancreatitis and intra-abdominal hypertension, SS‑31 reversed mitochondrial dysfunction in the diaphragm.

    In plain wordsIn septic rats, SS‑31 reversed mitochondrial dysfunction in the diaphragm.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseDiaphragm mitochondrial dysfunction
    Study

    ratn = 5

    Septic rat model of severe acute pancreatitis with intra-abdominal hypertension
    Comparator
    SAP+IAH rats
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, SS-31 could reverse atrophy of myofibres in SAP+IAH rats, as well as contractile dysfunction and mitochondrial dysfunction in the diaphragm.
    1 context sentence
    Summary · context
    Methods The rats were assigned at random to four groups: (1) control (n = 5), (2) SAP (n = 5), (3) SAP+IAH (n = 5), and (4) SAP+IAH+SS-31 (n = 5).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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