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Study · Animal study (in vivo) · rat · 2017

7 results

Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights.

Duzel A, Vlainic J, Antunovic M, Malekinusic D, Vrdoljak B, Samara M, Gojkovic S, Krezic I, Vidovic T, Bilic Z, Knezevic M, Sever M and 10 more

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Lojo N, Kokot A, Kolovrat M, Drmic D, Vukojevic J, Kralj T, Kasnik K, Siroglavic M, Seiwerth S, Sikiric P

World journal of gastroenterology1 Dec 2017Cited by 62 (Europe PMC)

PMID29358856 (opens in a new tab)PMCIDPMC5752708 (opens in a new tab)DOI10.3748/wjg.v23.i48.8465 (opens in a new tab)PepBankPUB-29358856
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemic colitis, a BPC‑157 bath of the colon segment increased vessel presentation.

    In plain wordsIn rats with a blood-deprived colon, BPC‑157 applied to the colon increased visible blood vessels.

    Peptide
    BPC-157
    Outcome
    IncreaseVessel presentation in ischemic colon
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 μg/kg · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 (10 μg/kg) bath (1 mL/rat) increased vessel presentation
    1 context sentence
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemic colitis, inside and outside arcade interconnections quickly reappeared after BPC‑157 bath.

    In plain wordsIn rats with a blood-deprived colon, BPC‑157 helped blood vessel connections reappear quickly.

    Peptide
    BPC-157
    Outcome
    IncreaseCollateral (arcade) interconnections
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 μg/kg · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    inside/outside arcade interconnections quickly reappeared
    1 context sentence
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemic colitis, BPC‑157 bath preserved mucosal folds and markedly reduced pale areas.

    In plain wordsIn rats with a blood-deprived colon, BPC‑157 kept the gut lining folds and reduced pale damaged areas.

    Peptide
    BPC-157
    Outcome
    DecreaseMucosal folds and pale areas in ischemic colon
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 μg/kg · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    mucosal folds were preserved and the pale areas were small and markedly reduced.
    1 context sentence
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemic colitis, BPC‑157 counteracted the worsening effects induced by L-NAME and L-arginine.

    In plain wordsIn rats with a blood-deprived colon, BPC‑157 reduced the worsening caused by L-NAME and L-arginine.

    Peptide
    BPC-157
    Outcome
    DecreaseWorsening effects induced by L-NAME and L-arginine
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    BPC 157 counteracted worsening effects induced by L-NAME (5 mg) and L-arginine (100 mg).
    1 context sentence
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic colitis, MDA levels were normal in BPC‑157 treated animals.

    In plain wordsIn rats with a blood-deprived colon, BPC‑157 treatment came with normal levels of an oxidative stress marker.

    Peptide
    BPC-157
    Outcome
    DecreaseOxidative stress (MDA) in colon tissue
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    MDA- and NO-levels were normal in BPC 157 treated IC-rats
    2 context sentences
    Summary · context
    oxidative stress as MDA (increased (IC- and IC + RL-rats))
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic colitis, NO levels were normal in BPC‑157 treated animals, after being decreased in ischemia and increased in reperfusion.

    In plain wordsIn rats with a blood-deprived colon, BPC‑157 treatment came with normal nitric oxide levels.

    Peptide
    BPC-157
    Outcome
    MixedNitric oxide (NO) levels in colon tissue
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    MDA- and NO-levels were normal in BPC 157 treated IC-rats and IC + RL-rats.
    2 context sentences
    Summary · context
    and NO levels (decreased (IC-rats); increased (IC + RL-rats)
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ischemic colitis and obstruction, BPC‑157 bath left the mucosa almost completely spared on day 10, with small pale areas and only small adhesions.

    In plain wordsIn rats with a blocked, blood-deprived colon, BPC‑157 left the gut lining almost fully spared after 10 days.

    Peptide
    BPC-157
    Outcome
    DecreaseMucosal damage after ischemia with obstruction (day 10)
    Study

    ratn: not reported in source

    ischemic colitis, reperfusion and obstruction
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · bath on colon segmentAs given in this study (rat).

    Source sentences

    Summary
    In addition, on day 10, BPC 157-treated IC + OB-rats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects; the treated colon segment was of normal diameter, and only small adhesions were present.
    1 context sentence
    Summary · context
    To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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