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Study · Not a test of the peptide alone · 2018

7 results

Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors.

Gottardo MF, Pidre ML, Zuccato C, Asad AS, Imsen M, Jaita G, Candolfi M, Romanowski V, Seilicovich A

Apoptosis : an international journal on programmed cell death1 Feb 2018Cited by 20 (Europe PMC)

PMID29352443 (opens in a new tab)DOI10.1007/s10495-018-1444-0 (opens in a new tab)PepBankPUB-29352443
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In nude mice with GH3 tumors, intratumor injection of BV-shHNr increased the number of apoptotic cells.

    In plain wordsIn mice with pituitary tumors, injecting the silencing virus into the tumor increased dying tumor cells.

    Peptide
    Humanin
    Outcome
    IncreaseApoptotic cells in tumors
    Study

    mousen: not reported in source

    Nude mice with s.c. GH3 tumors
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Intratumor injection of BV-shHNr to nude mice bearing s.c. GH3 tumors increased the number of apoptotic cells, delayed tumor growth and enhanced survival rate, suggesting that endogenous HNr may be involved in pituitary tumor progression.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In nude mice with GH3 tumors, intratumor injection of BV-shHNr delayed tumor growth.

    In plain wordsIn mice with pituitary tumors, injecting the silencing virus into the tumor slowed tumor growth.

    Peptide
    Humanin
    Outcome
    DecreaseTumor growth
    Study

    mousen: not reported in source

    Nude mice with s.c. GH3 tumors
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Intratumor injection of BV-shHNr to nude mice bearing s.c. GH3 tumors increased the number of apoptotic cells, delayed tumor growth and enhanced survival rate, suggesting that endogenous HNr may be involved in pituitary tumor progression.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In nude mice with GH3 tumors, intratumor injection of BV-shHNr enhanced the survival rate.

    In plain wordsIn mice with pituitary tumors, injecting the silencing virus into the tumor improved survival.

    Peptide
    Humanin
    Outcome
    IncreaseSurvival rate
    Study

    mousen: not reported in source

    Nude mice with s.c. GH3 tumors
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Intratumor injection of BV-shHNr to nude mice bearing s.c. GH3 tumors increased the number of apoptotic cells, delayed tumor growth and enhanced survival rate, suggesting that endogenous HNr may be involved in pituitary tumor progression.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In GH3 pituitary tumor cells, plasmid shRNA that silences HNr increased apoptosis.

    In plain wordsIn pituitary tumor cells, switching off the rat humanin gene with shRNA increased cell death.

    Peptide
    Humanin
    Outcome
    IncreaseApoptosis after pUC-shHNr transfection
    Study

    n: not reported in source

    GH3 somatolactotrope cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Transfection of somatolactotrope GH3 cells with pUC-shHNr increased apoptosis, suggesting that endogenous HNr plays a cytoprotective role in pituitary tumor cells.
    1 context sentence
    Summary · context
    Thus, we used RNA interference based on short-hairpin RNA (shRNA) targeted to HNr (shHNr).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In vitro, BV-shRNA transduced more than 80% of GH3 cells.

    In plain wordsIn lab tests, the virus carrying the silencing gene entered more than 80% of pituitary tumor cells.

    Peptide
    Humanin
    Outcome
    Not applicableBaculovirus transduction efficiency
    Study

    n: not reported in source

    GH3 cells
    Outcome group
    Tumor growth · Cancer

    Measurements

    Transduced cells
    > 80%
    GH3 cells, BV-shRNA

    Source sentences

    Summary
    In vitro, BV-shRNA was capable of transducing more than 80% of GH3 cells and decreased HNr mRNA.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In GH3 cells, BV-shRNA decreased HNr mRNA.

    In plain wordsIn pituitary tumor cells, the silencing virus lowered rat humanin mRNA.

    Peptide
    Humanin
    Outcome
    DecreaseHNr mRNA
    Study

    n: not reported in source

    GH3 cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    In vitro, BV-shRNA was capable of transducing more than 80% of GH3 cells and decreased HNr mRNA.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  7. 07LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In GH3 cells, baculovirus encoding shHNr increased apoptosis in transduced cells.

    In plain wordsIn pituitary tumor cells, the silencing virus increased cell death.

    Peptide
    Humanin
    Outcome
    IncreaseApoptosis in BV-shHNr transduced cells
    Study

    n: not reported in source

    GH3 cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Also, BV-shHNr increased apoptosis in transduced GH3 cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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