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Study · In vitro (cells) · 2018

9 results

Effects of thymosin β4 on oxygen‑glucose deprivation and reoxygenation‑induced injury.

Ji H, Xu L, Wang Z, Fan X, Wu L

International journal of molecular medicine9 Jan 2018Cited by 6 (Europe PMC)

PMID29328391 (opens in a new tab)DOI10.3892/ijmm.2018.3369 (opens in a new tab)PepBankPUB-29328391
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to OGD/R, Tβ4 pre-conditioning significantly increased cell survival.

    In plain wordsIn cells, Tβ4 given before oxygen and glucose loss helped more nerve-like cells survive.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell survival after OGD/R
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 significantly increased cell survival after OGD/R.
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  2. 02LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to OGD/R, Tβ4 inhibited the release of lactate dehydrogenase.

    In plain wordsIn cells, Tβ4 reduced the release of lactate dehydrogenase, a marker of cell damage.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLactate dehydrogenase release
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 inhibited the release of lactate dehydrogenase
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  3. 03LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 downregulated malondialdehyde.

    In plain wordsIn cells, Tβ4 lowered malondialdehyde, a marker of oxidative damage.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMalondialdehyde level
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    downregulated malondialdehyde and upregulated the activities of glutathione peroxidase and superoxide dismutase.
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  4. 04LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 upregulated the activity of glutathione peroxidase.

    In plain wordsIn cells, Tβ4 raised the activity of glutathione peroxidase, an antioxidant enzyme.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseGlutathione peroxidase activity
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    upregulated the activities of glutathione peroxidase
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  5. 05LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 upregulated the activity of superoxide dismutase.

    In plain wordsIn cells, Tβ4 raised the activity of superoxide dismutase, an antioxidant enzyme.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSuperoxide dismutase activity
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    upregulated the activities of glutathione peroxidase and superoxide dismutase
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  6. 06LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 attenuated the OGD/R-associated decrease in P62 expression.

    In plain wordsIn cells, Tβ4 reduced the drop in P62 caused by oxygen and glucose loss.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseP62 expression
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Cell viability and death · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 attenuated OGD/R‑associated decreases in the expression of P62 and the anti‑apoptotic protein B‑cell lymphoma‑2, as well as the upregulation of autophagy mediators, including autophagy‑related protein‑5 and the ratio of microtubule‑associated protein 1 light chain 3 (LC3) II vs. LC3 I.
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  7. 07LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 attenuated the OGD/R-associated decrease in the anti-apoptotic protein Bcl-2.

    In plain wordsIn cells, Tβ4 reduced the drop in the anti-cell-death protein Bcl-2 caused by oxygen and glucose loss.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseBcl-2 expression
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Cell viability and death · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 attenuated OGD/R‑associated decreases in the expression of P62 and the anti‑apoptotic protein B‑cell lymphoma‑2, as well as the upregulation of autophagy mediators, including autophagy‑related protein‑5 and the ratio of microtubule‑associated protein 1 light chain 3 (LC3) II vs. LC3 I.
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  8. 08LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 attenuated the OGD/R-associated upregulation of autophagy-related protein-5.

    In plain wordsIn cells, Tβ4 reduced the rise in autophagy-related protein-5 caused by oxygen and glucose loss.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAutophagy-related protein-5 expression
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Cell viability and death · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 attenuated OGD/R‑associated decreases in the expression of P62 and the anti‑apoptotic protein B‑cell lymphoma‑2, as well as the upregulation of autophagy mediators, including autophagy‑related protein‑5 and the ratio of microtubule‑associated protein 1 light chain 3 (LC3) II vs. LC3 I.
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.
  9. 09LabIn vitro (cells)Mechanism

    In PC12 cells exposed to OGD/R, Tβ4 attenuated the OGD/R-associated upregulation of the LC3 II to LC3 I ratio.

    In plain wordsIn cells, Tβ4 reduced the rise in the LC3 II to LC3 I ratio, an autophagy marker, caused by oxygen and glucose loss.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLC3 II to LC3 I ratio
    Study

    n: not reported in source

    PC12 cells after oxygen-glucose deprivation and reoxygenation (OGD/R)
    Outcome group
    Cell viability and death · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 attenuated OGD/R‑associated decreases in the expression of P62 and the anti‑apoptotic protein B‑cell lymphoma‑2, as well as the upregulation of autophagy mediators, including autophagy‑related protein‑5 and the ratio of microtubule‑associated protein 1 light chain 3 (LC3) II vs. LC3 I.
    2 context sentences
    Summary · context
    The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R).
    Summary · context
    Tβ4 pre‑conditioning prior to OGD/R was performed to evaluate PC12‑cell viability and the protective mechanisms of Tβ4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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