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Study · Not a test of the peptide alone · 2018

2 results

Intergenerational Influence of Paternal Obesity on Metabolic and Reproductive Health Parameters of the Offspring: Male-Preferential Impact and Involvement of Kiss1-Mediated Pathways.

Sanchez-Garrido MA, Ruiz-Pino F, Velasco I, Barroso A, Fernandois D, Heras V, Manfredi-Lozano M, Vazquez MJ, Castellano JM, Roa J, Pinilla L, Tena-Sempere M

Endocrinology1 Feb 2018Cited by 45 (Europe PMC)

PMID29309558 (opens in a new tab)DOI10.1210/en.2017-00705 (opens in a new tab)PepBankPUB-29309558
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In male rat offspring fed a high-fat diet, paternal obesity was associated with suppressed LH responses to central kisspeptin‑10.

    In plain wordsIn male rats fed a high-fat diet, having an obese father went with a weaker LH response to kisspeptin‑10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH response to kisspeptin-10, male offspring
    Study

    ratn: not reported in source

    Male offspring of obese fathers fed a high-fat diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    LH responses to central kisspeptin-10 administration were also suppressed in HFD males from obese fathers.
    1 context sentence
    Summary · context
    Lean and obese male rats were mated with lean virgin female rats; male and female offspring were fed HFD from weaning onward and analyzed at adulthood.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    In female rat offspring fed a high-fat diet, paternal obesity was associated with reduced LH responses to kisspeptin‑10.

    In plain wordsIn female rats fed a high-fat diet, having an obese father went with a weaker LH response to kisspeptin‑10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseLH response to kisspeptin-10, female offspring
    Study

    ratn: not reported in source

    Female offspring of obese fathers fed a high-fat diet
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In contrast, paternal obesity did not significantly alter gonadotropin levels in the female offspring fed HFD, although these females displayed reduced LH responses to kisspeptin-10.
    1 context sentence
    Summary · context
    Lean and obese male rats were mated with lean virgin female rats; male and female offspring were fed HFD from weaning onward and analyzed at adulthood.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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