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Study · Measured the body's own peptide · 2018

5 results

Kisspeptin as a new serum biomarker to discriminate miscarriage from viable intrauterine pregnancy.

Sullivan-Pyke C, Haisenleder DJ, Senapati S, Nicolais O, Eisenberg E, Sammel MD, Barnhart KT

Fertility and sterility1 Jan 2018Cited by 40 (Europe PMC)

PMID29307393 (opens in a new tab)PMCIDPMC5771501 (opens in a new tab)DOI10.1016/j.fertnstert.2017.09.029 (opens in a new tab)PepBankPUB-29307393
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In women with viable pregnancy, miscarriage or no pregnancy, serum kisspeptin levels differed between the pregnant and nonpregnant state and by viability.

    In plain wordsWomen's own kisspeptin levels in blood differed between pregnant and nonpregnant women, and between viable pregnancies and miscarriages.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Direction not reportedSerum kisspeptin by pregnancy state and viability
    Study

    n = 59

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Kisspeptin levels differed between the pregnant and nonpregnant state and by viability.
    1 context sentence
    Summary · context
    Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In women with miscarriage, serum kisspeptin had a significant positive association with hCG.

    In plain wordsIn women with miscarriage, the body's own kisspeptin levels were linked to higher hCG levels.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseSerum kisspeptin and hCG in miscarriage
    Study

    n = 20

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    There was also a significant positive association with hCG in SAB, but not in IUP.
    1 context sentence
    Summary · context
    Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In women with viable intrauterine pregnancy, serum kisspeptin had no significant association with hCG.

    In plain wordsIn women with viable pregnancies, the body's own kisspeptin levels were not linked to hCG levels.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeSerum kisspeptin and hCG in viable pregnancy
    Study

    n = 20

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    There was also a significant positive association with hCG in SAB, but not in IUP.
    1 context sentence
    Summary · context
    Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In early pregnancy, serum kisspeptin levels were positively associated with gestational age.

    In plain wordsIn early pregnancy, the body's own kisspeptin levels were linked to higher levels at later gestational ages.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseSerum kisspeptin and gestational age
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Kisspeptin levels were positively associated with gestational age.
    1 context sentence
    Summary · context
    Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19).

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-54 (metastin).

  1. 05HumanNot a test of Kisspeptin-54 (metastin) aloneObservational studyOther

    A serum kisspeptin assay had a limit of detection of 0.024 ng/mL and intra- and interassay coefficients of variation of 5.1% and 8.6%.

    In plain wordsA blood test for kisspeptin could detect very low levels and gave consistent results between runs.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKisspeptin serum assay performance
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Limit of detection
    0.024 ng/mL
    serum kisspeptin assay
    Intra-assay CV
    5.1%
    serum kisspeptin assay
    Interassay CV
    8.6%
    serum kisspeptin assay

    Source sentences

    Summary
    The limit of detection was 0.024 ng/mL; intra- and interassay coefficients of variation were 5.1% and 8.6%, respectively.
    1 context sentence
    Summary · context
    Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19).

    In this study, Kisspeptin-54 (metastin) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-54 (metastin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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