Serum thymosin beta4 as a noninvasive biomarker in patients with nonalcoholic steatohepatitis.

Jiang Y, Han T, Zhang ZG, Zhang Y, Qi FX

Revista espanola de enfermedades digestivas1 Jan 2018Cited by 4 (Europe PMC)

PMID29271227DOI10.17235/reed.2017.4690/2016PepBankPUB-29271227

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults with fatty liver disease, serum Tβ4 was lower in patients with NASH than in patients with NAFL.
In plain wordsIn adults with fatty liver disease, the body's own Tβ4 level in blood was lower in NASH than in NAFL.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSerum Tβ4 in NASH versus NAFL
Study
n = 45
Comparator
NAFL patients
Outcome group
Liver fat and liver function · Liver
Measurements
Serum Tβ4
5.12 mg/l
NAFL group
Serum Tβ4
2.98 mg/l
NASH group
Source sentences
Summary
Serum Tβ4 content was 5.12 ± 1.87 mg/l in the NAFL group and 2.98 ± 1.35 mg/l in the NASH group (p < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122701
02HumanEndogenous levelObservational studyOther
In adults with fatty liver disease, a serum Tβ4 cut-off of 3.94 mg/l detected NASH with higher sensitivity and specificity than ALT.
In plain wordsIn adults with fatty liver disease, the body's own Tβ4 level in blood detected NASH better than the liver enzyme ALT.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableROC cut-off of serum Tβ4 for detecting NASH
Study
n = 45
Outcome group
Liver fat and liver function · Liver
Measurements
Cut-off
3.94 mg/l
NASH detection
Sensitivity
85.7%
Tβ4 cut-off
Specificity
79.2%
Tβ4 cut-off
Source sentences
Summary
On the basis of ROC analysis, the best predictive Tβ4 cut-off value for detecting NASH was 3.94 mg/l (85.7% sensitivity and 79.2% specificity, which were higher than those of ALT).
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122709
03HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with the NAFLD histological activity score.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to a higher liver damage score.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with NAFLD activity score in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.53 r
NAS
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122702
04HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with histological hepatic steatosis.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to more liver fat on biopsy.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with hepatic steatosis in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.562 r
hepatic steatosis
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122703
05HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with lobular inflammation.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to more liver inflammation on biopsy.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with lobular inflammation in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.574 r
lobular inflammation
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122704
06HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with hepatocyte ballooning.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to more liver cell ballooning on biopsy.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with ballooning in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.438 r
ballooning
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122705
07HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with ALT.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to higher ALT, a liver enzyme.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with ALT in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.446 r
ALT
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122706
08HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with glucose.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to higher blood glucose.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with glucose in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.426 r
glucose
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122707
09HumanEndogenous levelObservational studyOther
In patients with NASH, serum Tβ4 was negatively correlated with 8-OhdG, a marker of oxidative DNA damage.
In plain wordsIn people with NASH, lower body's own Tβ4 levels were linked to higher 8-OhdG, a marker of oxidative damage.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of serum Tβ4 with 8-OhdG in NASH
Study
n = 21
Outcome group
Liver fat and liver function · Liver
Measurements
Correlation coefficient
−0.563 r
8-OhdG
Source sentences
Summary
Serum Tβ4 content and NAS, histological features of hepatic steatosis, lobular inflammation and ballooning, ALT, glucose and 8-OhdG levels were negatively correlated (p < 0.05 for all) in the NASH group. The correlation coefficient values were -0.530, -0.562, -0.574, -0.438, -0.446, -0.426 and -0.563, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The study included 24 NAFL patients and 21 NASH patients.
Summary · context
The levels of Tβ4, 8-hydroxydeoxyguanosine acid (8-OhdG), liver function parameters, blood lipid, and glucose were detected in the venous blood of all patients.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2927122708

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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