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Study · Animal study (in vivo) · pig · 2018

10 results

Mitochondrial targeted peptides preserve mitochondrial organization and decrease reversible myocardial changes in early swine metabolic syndrome.

Yuan F, Woollard JR, Jordan KL, Lerman A, Lerman LO, Eirin A

Cardiovascular research1 Mar 2018Cited by 23 (Europe PMC)

PMID29267873 (opens in a new tab)PMCIDPMC6018752 (opens in a new tab)DOI10.1093/cvr/cvx245 (opens in a new tab)PepBankPUB-29267873
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved myocardial mitochondrial organization.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved the structure of heart mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial organization
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H202 production, and improved generation of NADPH and GSH.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved the myocardial cardiolipin species profile.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved the mix of a key mitochondrial membrane fat in the heart.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCardiolipin species profile
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H202 production, and improved generation of NADPH and GSH.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide restored the myocardial ATP/ADP ratio.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored the energy balance in heart tissue.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseATP/ADP ratio
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H202 production, and improved generation of NADPH and GSH.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide restored myocardial cytochrome-c oxidase IV activity.

    In plain wordsIn pigs with metabolic syndrome, elamipretide restored the activity of a mitochondrial enzyme in the heart.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCOX-IV activity
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H202 production, and improved generation of NADPH and GSH.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide decreased myocardial mitochondrial H2O2 production.

    In plain wordsIn pigs with metabolic syndrome, elamipretide lowered hydrogen peroxide production in heart mitochondria.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMitochondrial H2O2 production
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H202 production, and improved generation of NADPH and GSH.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved myocardial generation of NADPH and GSH.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved the heart's production of two antioxidant molecules.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseNADPH and GSH generation
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H202 production, and improved generation of NADPH and GSH.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved cytoskeletal-mitochondria-sarcoplasmic reticulum interaction.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved how mitochondria connect with other structures in heart cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseCytoskeletal-mitochondria-SR interaction
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM also improved cytoskeletal-mitochondria-SR interaction and mitochondrial calcium handling, attenuating oxidative stress, and apoptosis.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide improved mitochondrial calcium handling.

    In plain wordsIn pigs with metabolic syndrome, elamipretide improved how heart mitochondria handle calcium.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial calcium handling
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM also improved cytoskeletal-mitochondria-SR interaction and mitochondrial calcium handling, attenuating oxidative stress, and apoptosis.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide attenuated myocardial oxidative stress.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reduced oxidative stress in the heart.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial oxidative stress
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM also improved cytoskeletal-mitochondria-SR interaction and mitochondrial calcium handling, attenuating oxidative stress, and apoptosis.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with diet-induced metabolic syndrome, elamipretide attenuated myocardial apoptosis.

    In plain wordsIn pigs with metabolic syndrome, elamipretide reduced cell death in the heart.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMyocardial apoptosis
    Study

    pign = 6

    Diet-induced metabolic syndrome in domestic pigs
    Comparator
    Untreated MetS pigs
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    0.1 mg/kg once daily · subcutaneous · 4 weeksAs given in this study (pig).

    Source sentences

    Summary
    ELAM also improved cytoskeletal-mitochondria-SR interaction and mitochondrial calcium handling, attenuating oxidative stress, and apoptosis.
    1 context sentence
    Summary · context
    Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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