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Study · In vitro (cell-free) · 2018

6 results

Humanin decreases mitochondrial membrane permeability by inhibiting the membrane association and oligomerization of Bax and Bid proteins.

Ma ZW, Liu DX

Acta pharmacologica Sinica21 Dec 2017Cited by 32 (Europe PMC)

PMID29265109 (opens in a new tab)PMCIDPMC6256269 (opens in a new tab)DOI10.1038/aps.2017.169 (opens in a new tab)PepBankPUB-29265109
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In lipid bilayers, HN at 100 nmol/L inhibited the self-association of Bax.

    In plain wordsIn lab tests, humanin reduced Bax proteins clumping together in a lipid membrane.

    Peptide
    Humanin
    Outcome
    DecreaseBax self-association with lipid bilayers
    Study

    n: not reported in source

    Lipid bilayers with Bax and Bid proteins
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    100 nmol/LAs given in this study.

    Source sentences

    Summary
    HN (100 nmol/L) inhibited the self-association and tBid-activated association of Bax with the bilayers
    1 context sentence
    Summary · context
    In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their oligomerization in the membrane.
  2. 02LabIn vitro (cell-free)Mechanism

    In lipid bilayers, HN at 100 nmol/L inhibited the tBid-activated association of Bax with the bilayers.

    In plain wordsIn lab tests, humanin reduced tBid-triggered binding of Bax to a lipid membrane.

    Peptide
    Humanin
    Outcome
    DecreasetBid-activated association of Bax with bilayers
    Study

    n: not reported in source

    Lipid bilayers with Bax and Bid proteins
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    100 nmol/LAs given in this study.

    Source sentences

    Summary
    HN (100 nmol/L) inhibited the self-association and tBid-activated association of Bax with the bilayers
    1 context sentence
    Summary · context
    In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their oligomerization in the membrane.
  3. 03LabIn vitro (cell-free)Mechanism

    In lipid bilayers, HN at 100 nmol/L significantly decreased the proportion of Bax in tetramers.

    In plain wordsIn lab tests, humanin lowered the share of Bax found in groups of four.

    Peptide
    Humanin
    Outcome
    DecreaseProportion of Bax in tetramers
    Study

    n: not reported in source

    Lipid bilayers with Bax and Bid proteins
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    100 nmol/LAs given in this study.

    Source sentences

    Summary
    significantly decreased the proportion of Bax in tetramers.
    1 context sentence
    Summary · context
    In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their oligomerization in the membrane.
  4. 04LabIn vitro (cell-free)Mechanism

    HN inhibited Bid translocation to lipid bilayers.

    In plain wordsIn lab tests, humanin stopped Bid protein from moving to a lipid membrane.

    Peptide
    Humanin
    Outcome
    DecreaseBid translocation to lipid bilayers
    Study

    n: not reported in source

    Lipid bilayers with Bax and Bid proteins
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HN inhibited Bid translocation to lipid bilayers.
    1 context sentence
    Summary · context
    In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their oligomerization in the membrane.
  5. 05LabIn vitro (cell-free)Mechanism

    HN bound to Bax and Bid either in solution or in the membrane.

    In plain wordsIn lab tests, humanin attached to Bax and Bid, both in solution and in a membrane.

    Peptide
    Humanin
    Outcome
    Not applicableBinding of HN to Bax and Bid
    Study

    n: not reported in source

    Lipid bilayers with Bax and Bid proteins
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN could bind with Bax and Bid either in solution or in the membrane.
    1 context sentence
    Summary · context
    In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their oligomerization in the membrane.
  6. 06LabIn vitro (cell-free)Mechanism

    HN could not pull Bax and Bid out of the membrane.

    In plain wordsIn lab tests, humanin could not remove Bax and Bid from a membrane.

    Peptide
    Humanin
    Outcome
    No significant changeRemoval of membrane-bound Bax and Bid by HN
    Study

    n: not reported in source

    Lipid bilayers with Bax and Bid proteins
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, HN could not pull the proteins out of the membrane.
    1 context sentence
    Summary · context
    In order to elucidate the molecular mechanisms of HN neuroprotection, we explored the effects of HN on the association of Bax or Bid with lipid bilayers and their oligomerization in the membrane.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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