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Study · In vitro (cells) · 2018

12 results

Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells.

Wu X, Song Y, Li S, Liu X, Hua W, Wang K, Liu W, Li S, Zhang Y, Shao Z, Yang C

International journal of immunopathology and pharmacology19 Dec 2017Cited by 14 (Europe PMC)

PMID29256292 (opens in a new tab)PMCIDPMC5849218 (opens in a new tab)DOI10.1177/0394632017747500 (opens in a new tab)PepBankPUB-29256292
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide could improve proliferation.

    In plain wordsIn cells under low oxygen, pramlintide could improve nucleus pulposus cell growth.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseCell proliferation
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Cell proliferation and differentiation · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results indicate that pramlintide could improve NP cell proliferation, glycolytic activity, and the ECM synthesis under hypoxia
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  2. 02LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide could improve glycolytic activity.

    In plain wordsIn cells under low oxygen, pramlintide could improve glycolytic activity.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseGlycolytic activity
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Metabolic pathways and metabolomics · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results indicate that pramlintide could improve NP cell proliferation, glycolytic activity, and the ECM synthesis under hypoxia
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  3. 03LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide could improve extracellular matrix synthesis.

    In plain wordsIn cells under low oxygen, pramlintide could improve extracellular matrix production.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseECM synthesis
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The results indicate that pramlintide could improve NP cell proliferation, glycolytic activity, and the ECM synthesis under hypoxia
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  4. 04LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide increased proteoglycan precipitation.

    In plain wordsIn cells under low oxygen, pramlintide increased proteoglycan precipitation.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseProteoglycan precipitation
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    which is evident from the increased precipitation of proteoglycans
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  5. 05LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide increased AGG protein expression.

    In plain wordsIn cells under low oxygen, pramlintide increased AGG protein levels.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseAGG expression
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased expression of AGG, Col2, and SOX9 proteins
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  6. 06LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide increased Col2 protein expression.

    In plain wordsIn cells under low oxygen, pramlintide increased Col2 protein levels.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseCol2 expression
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased expression of AGG, Col2, and SOX9 proteins
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  7. 07LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide increased SOX9 protein expression.

    In plain wordsIn cells under low oxygen, pramlintide increased SOX9 protein levels.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseSOX9 expression
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased expression of AGG, Col2, and SOX9 proteins
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  8. 08LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide decreased MMP3 protein expression.

    In plain wordsIn cells under low oxygen, pramlintide decreased MMP3 protein levels.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseMMP3 expression
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased expression of MMP3, MMP9, and MMP13 proteins
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  9. 09LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide decreased MMP9 protein expression.

    In plain wordsIn cells under low oxygen, pramlintide decreased MMP9 protein levels.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseMMP9 expression
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased expression of MMP3, MMP9, and MMP13 proteins
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  10. 10LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells under hypoxia, pramlintide decreased MMP13 protein expression.

    In plain wordsIn cells under low oxygen, pramlintide decreased MMP13 protein levels.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseMMP13 expression
    Study

    humann: not reported in source

    Human nucleus pulposus cells under hypoxia
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    decreased expression of MMP3, MMP9, and MMP13 proteins
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  11. 11LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells, pramlintide could facilitate survival through mitochondrial-mediated, Bcl-2/caspase-3-dependent apoptosis.

    In plain wordsIn cells, pramlintide could improve nucleus pulposus cell survival through mitochondrial and apoptosis pathways.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseCell survival through mitochondrial apoptotic signaling
    Study

    humann: not reported in source

    Human nucleus pulposus cells
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    And, pramlintide could facilitate the survival of NP cells through mitochondrial-mediated, Bcl-2/caspase-3-dependent apoptosis.
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.
  12. 12LabIn vitro (cells)Mechanism

    In human nucleus pulposus cells, pramlintide activated AKT-AMPK/mTOR signaling.

    In plain wordsIn cells, pramlintide activated AKT-AMPK/mTOR signaling.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseAKT-AMPK/mTOR signaling activation
    Study

    humann: not reported in source

    Human nucleus pulposus cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, activation of AKT-AMPK/mTOR signaling pathway is also observed by the treatment.
    2 context sentences
    Summary · context
    The goals of this study were to investigate the roles of pramlintide in the regulation of cell survival and matrix metabolism, and further explore their underlying mechanisms, in human nucleus pulposus (NP) cells.
    Summary · context
    NP cells were treated with different concentrations of pramlintide in normoxic or hypoxic conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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